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Table

From: High dose intravenous clonidine is superior to intravenous clomethiazole in severe alcohol withdrawal syndrome (delirium tremens)

 

Clonidine

Clomethiazole

Initial dose

0.56 ± 0.22 mg

0.78 ± 0.56 mg

Maintenance dose

  2.2 ± 1.5 mg/day

  5.2 ± 2.5 mg/day

Duration of treatment

  

   ≤ 2 days

14 (32.6%)

7(14.6%)

   3-5 days

22 (51.2%)

22 (45.8%)

   6-10 days

3 (7.0%)

12 (25.0%)

Non-responder (≥ 10 days)

4 (9.3%)

7 (14.6%)

Enteral nutrition day 5

20 (46.5%)

12 (25%)

Mobilisation

  

   Regular respiration

35 (81.4%)

27 (56.3%)

   Regular bowel function day 2

24 (55.8%)

36 (75%)

   Regular bowel function day 4

24 (55.8%)

39 (81.3%)

Additive sedatives necessary

36 (83.7%)

24 (50%)