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Table 2 Flavocoxid effects on liver histologic damage in CLP mice

From: RETRACTED ARTICLE: Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis

Parameter

Sham

Sham + flavocoxid

CLP

CLP + flavocoxid

Inflammatory infiltrate

0

0

2.52 ± 0.52

1.55 ± 0.46a

Steatosis

0

0

2.33 ± 0.41

1.47 ± 0.26a

Necrosis

0

0

2.77 ± 0.23

0b

Ballooning degeneration

0

0

2.17 ± 0.26

0.21 ± 0.12b

  1. Histologic grading as reported in Methods; six mice per group treated with flavocoxid (20 mg/kg, ip). a P < 0.05 versus CLP; b P < 0.001 versus CLP.