Skip to main content

Table 2 Flavocoxid effects on liver histologic damage in CLP mice

From: Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis

Parameter Sham Sham + flavocoxid CLP CLP + flavocoxid
Inflammatory infiltrate 0 0 2.52 ± 0.52 1.55 ± 0.46a
Steatosis 0 0 2.33 ± 0.41 1.47 ± 0.26a
Necrosis 0 0 2.77 ± 0.23 0b
Ballooning degeneration 0 0 2.17 ± 0.26 0.21 ± 0.12b
  1. Histologic grading as reported in Methods; six mice per group treated with flavocoxid (20 mg/kg, ip). aP < 0.05 versus CLP; bP < 0.001 versus CLP.