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Table 1 Flavocoxid effects on lung histologic damage in CLP mice

From: Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis

Parameter Sham Sham + flavocoxid CLP CLP + flavocoxid
Inflammatory infiltrate 0 0 2.27 ± 0.59 1.15 ± 0.57a
Vascular congestion 0 0 2.12 ± 0.20 1.25 ± 0.27a
Interstitial edema 0 0 2.33 ± 0.41 1.25 ± 0.52a
  1. Histologic grading as reported in Methods; six mice per group treated with flavocoxid (20 mg/kg, ip).aP < 0.05 versus CLP.