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Table 1 Flavocoxid effects on lung histologic damage in CLP mice

From: RETRACTED ARTICLE: Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis

Parameter

Sham

Sham + flavocoxid

CLP

CLP + flavocoxid

Inflammatory infiltrate

0

0

2.27 ± 0.59

1.15 ± 0.57a

Vascular congestion

0

0

2.12 ± 0.20

1.25 ± 0.27a

Interstitial edema

0

0

2.33 ± 0.41

1.25 ± 0.52a

  1. Histologic grading as reported in Methods; six mice per group treated with flavocoxid (20 mg/kg, ip).a P < 0.05 versus CLP.