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Figure 1 | Critical Care

Figure 1

From: Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis

Figure 1

Effect of flavocoxid on survival in mice with cecal ligation and puncture (CLP). C57BL/6J mice were subjected to CLP (n = 15 per group) or sham operation (n = 10 per group). All the CLP animals were fluid resuscitated with sterile NaCl 0.9% saline solution (1 ml/mouse). Animals were treated with flavocoxid (20 mg/kg, ip) with and without gentamicin (3.2 mg/kg, sc), or baicalin (16 mg/kg, ip), or cathechin (4 mg/kg, ip), or vehicle (NaCl 0.9%) 1 hour after surgery, repeated every 12 hours. Mouse survival was monitored every 24 hours for a total of 120 hours, and expressed as percentage of mice survived at each time point. *P < 0.01 compared with sham + vehicle or flavocoxid; #P < 0.01 compared with CLP + vehicle; §P < 0.01 compared with CLP + vehicle.

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