Articles
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Citation: Critical Care 2024 28:67
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Impact of hyperoxia on the gut during critical illnesses
Molecular oxygen is typically delivered to patients via oxygen inhalation or extracorporeal membrane oxygenation (ECMO), potentially resulting in systemic hyperoxia from liberal oxygen inhalation or localized ...
Citation: Critical Care 2024 28:66 -
Imatinib treatment improves hyperglycaemic dysregulation in severe COVID-19: a secondary analysis of blood biomarkers in a randomised controlled trial
SARS-CoV-2 can induce insulin resistance, which is, among others, mediated by adipose tissue dysfunction and reduced angiotensin-converting enzyme 2 (ACE2) enzymatic activity. In SARS-CoV-2-infected mice, the ...
Citation: Critical Care 2024 28:65 -
Prevention of post-operative delirium using an overnight infusion of dexmedetomidine in patients undergoing cardiac surgery: a pragmatic, randomized, double-blind, placebo-controlled trial
After cardiac surgery, post-operative delirium (PoD) is acknowledged to have a significant negative impact on patient outcome. To date, there is no valuable and specific treatment for PoD. Critically ill patie...
Citation: Critical Care 2024 28:64 -
Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia
Acute respiratory distress syndrome (ARDS) is a life-threatening critical care syndrome commonly associated with infections such as COVID-19, influenza, and bacterial pneumonia. Ongoing research aims to improv...
Citation: Critical Care 2024 28:63 -
The use of mechanical CPR for IHCA during the COVID-19 pandemic as compared to the pre-pandemic period
Citation: Critical Care 2024 28:62 -
Violence against healthcare professionals in intensive care units: a systematic review and meta-analysis of frequency, risk factors, interventions, and preventive measures
To assess the frequency, risk factors, consequences, and prevention of violence against healthcare workers in intensive care units.
Citation: Critical Care 2024 28:61 -
How often do we need to update PEEP setting during prone positioning in ARDS?
Citation: Critical Care 2024 28:60 -
Reflections on epidemiological investigations of sepsis in the Asian Region
Citation: Critical Care 2024 28:59 -
Improving management of ARDS: uniting acute management and long-term recovery
Acute Respiratory Distress Syndrome (ARDS) is an important global health issue with high in-hospital mortality. Importantly, the impact of ARDS extends beyond the acute phase, with increased mortality and disa...
Citation: Critical Care 2024 28:58 -
Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: an updated meta-analysis and trial sequential analysis
Extracorporeal cardiopulmonary resuscitation (ECPR) may reduce mortality and improve neurological outcomes in patients with cardiac arrest. We updated our existing meta-analysis and trial sequential analysis t...
Citation: Critical Care 2024 28:57 -
Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial
Despite evidence associating inflammatory biomarkers with worse outcomes in hospitalized adults with COVID-19, trials of immunomodulatory therapies have met with mixed results, likely due in part to biological...
Citation: Critical Care 2024 28:56 -
Evidence supports the use of hydrocortisone for patients with community-acquired pneumonia
Citation: Critical Care 2024 28:55 -
Healthcare-associated infections in patients with severe COVID-19 supported with extracorporeal membrane oxygenation: a nationwide cohort study
Both critically ill patients with coronavirus disease 2019 (COVID-19) and patients receiving extracorporeal membrane oxygenation (ECMO) support exhibit a high incidence of healthcare-associated infections (HAI...
Citation: Critical Care 2024 28:54 -
Cardiogenic shock: all hail the RCT, long live the registry
Citation: Critical Care 2024 28:53 -
Coexistence of a fluid responsive state and venous congestion signals in critically ill patients: a multicenter observational proof-of-concept study
Current recommendations support guiding fluid resuscitation through the assessment of fluid responsiveness. Recently, the concept of fluid tolerance and the prevention of venous congestion (VC) have emerged as...
Citation: Critical Care 2024 28:52 -
The administration of four-factor prothrombin complex concentrate exacerbates thrombin generation in trauma patients at risk of massive transfusion: an ancillary study of the PROCOAG trial
Citation: Critical Care 2024 28:51 -
Phenotype-specific therapeutic efficacy of ilofotase alfa in patients with sepsis-associated acute kidney injury
There is no effective treatment for sepsis-associated acute kidney injury (SA-AKI). Ilofotase alfa (human recombinant alkaline phosphatase) has been shown to exert reno-protective properties, although it remai...
Citation: Critical Care 2024 28:50 -
Understanding the nebulisation of antibiotics: the key role of lung microdialysis studies
Nebulisation of antibiotics is a promising treatment for ventilator-associated pneumonia (VAP) caused by multidrug-resistant organisms. Ensuring effective antibiotic concentrations at the site of infection in ...
Citation: Critical Care 2024 28:49 -
Ketamine versus etomidate as an induction agent for tracheal intubation in critically ill adults: a Bayesian meta-analysis
Tracheal intubation is a high-risk intervention commonly performed in critically ill patients. Due to its favorable cardiovascular profile, ketamine is considered less likely to compromise clinical outcomes. T...
Citation: Critical Care 2024 28:48 -
Trauma systems in Asian countries: challenges and recommendations
Trauma burden is one of the leading causes of young human life and economic loss in low- and middle-income countries. Improved emergency and trauma care systems may save up to 2 million lives in these countries.
Citation: Critical Care 2024 28:47 -
Administration of methylene blue in septic shock: pros and cons
Septic shock typically requires the administration of vasopressors. Adrenergic agents remain the first choice, namely norepinephrine. However, their use to counteract life-threatening hypotension comes with po...
Citation: Critical Care 2024 28:46 -
Transforming research to improve therapies for trauma in the twenty-first century
Improvements have been made in optimizing initial care of trauma patients, both in prehospital systems as well as in the emergency department, and these have also favorably affected longer term outcomes. Howev...
Citation: Critical Care 2024 28:45 -
Procalcitonin for the diagnosis of postoperative bacterial infection after adult cardiac surgery: a systematic review and meta-analysis
Patients undergoing cardiac surgery are subject to infectious complications that adversely affect outcomes. Rapid identification is essential for adequate treatment. Procalcitonin (PCT) is a noninvasive blood ...
Citation: Critical Care 2024 28:44 -
Albumin versus saline infusion for sepsis-related peripheral tissue hypoperfusion: a proof-of-concept prospective study
Albumin has potential endothelial protective effects through antioxidant and anti-inflammatory properties. However, the effect of albumin on peripheral tissue perfusion in human sepsis remains poorly known.
Citation: Critical Care 2024 28:43 -
qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in the emergency department: a randomized controlled trial
Sepsis guidelines suggest immediate start of resuscitation for patients with quick Sequential Organ Failure Assessment (qSOFA) 2 or 3. However, the interpretation of qSOFA 1 remains controversial. We investiga...
Citation: Critical Care 2024 28:42 -
Thiamine administration in septic shock: a post hoc analysis of two randomized trials
This is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration on kidney protection and mortality in patients with septic shock.
Citation: Critical Care 2024 28:41 -
Antibiotic definitive treatment in ventilator associated pneumonia caused by AmpC-producing Enterobacterales in critically ill patients: a prospective multicenter observational study
Ventilator associated pneumonia (VAP) due to wild-type AmpC-producing Enterobacterales (wtAE) is frequent in intensive care unit (ICU) patients. Despite a low level of evidence, definitive antimicrobial therap...
Citation: Critical Care 2024 28:40 -
Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial
Volume replacement with crystalloid fluid is the conventional treatment of hemorrhage. We challenged whether a standardized amount of 5% or 20% albumin could be a viable option to maintain the blood volume dur...
Citation: Critical Care 2024 28:39 -
Combining proteins with n-3 PUFAs (EPA + DHA) and their inflammation pro-resolution mediators for preservation of skeletal muscle mass
The optimal feeding strategy for critically ill patients is still debated, but feeding must be adapted to individual patient needs. Critically ill patients are at risk of muscle catabolism, leading to loss of ...
Citation: Critical Care 2024 28:38 -
Response to: the association between time definition of reintubation and patient outcomes in critically ill patients—several topics should be noticed
Citation: Critical Care 2024 28:37 -
The protective effect of apolipoprotein H in paediatric sepsis
Sepsis is a severe condition characterized by acute organ dysfunction resulting from an imbalanced host immune response to infections. Apolipoprotein H (APOH) is a critical plasma protein that plays a crucial ...
Citation: Critical Care 2024 28:36 -
Trajectories of post-traumatic stress in sepsis survivors two years after ICU discharge: a secondary analysis of a randomized controlled trial
Post-traumatic stress has been identified as a frequent long-term complication in survivors of critical illnesses after sepsis. Little is known about long-term trajectories of post-traumatic stress and potenti...
Citation: Critical Care 2024 28:35 -
Time in ICU and post-intensive care syndrome: how long is long enough?
Our understanding of post-ICU recovery is influenced by which patients are selected to study and treat. Many studies currently list an ICU length of stay of at least 24, 48, or 72 h as an inclusion criterion. ...
Citation: Critical Care 2024 28:34 -
Cerebral autoregulation in traumatic brain injury: ultra-low-frequency pressure reactivity index and intracranial pressure across age groups
The ultra-low-frequency pressure reactivity index (UL-PRx) has been established as a surrogate method for bedside estimation of cerebral autoregulation (CA). Although this index has been shown to be a predicto...
Citation: Critical Care 2024 28:33 -
Incidence, diagnosis, management and outcome of acute mesenteric ischaemia: a prospective, multicentre observational study (AMESI Study)
The aim of this multicentre prospective observational study was to identify the incidence, patient characteristics, diagnostic pathway, management and outcome of acute mesenteric ischaemia (AMI).
Citation: Critical Care 2024 28:32 -
Association between CA-125 and post-extubation respiratory failure: a cohort study
Citation: Critical Care 2024 28:31 -
Prognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings
There is conflicting evidence on association between quick sequential organ failure assessment (qSOFA) and sepsis mortality in ICU patients. The primary aim of this study was to determine the association betwe...
Citation: Critical Care 2024 28:30 -
Societal costs of sepsis in the Netherlands
Sepsis is a life-threatening syndrome characterized by acute loss of organ function due to infection. Sepsis survivors are at risk for long-term comorbidities, have a reduced Quality of Life (QoL), and are pro...
Citation: Critical Care 2024 28:29 -
Effect of prehospital high-dose glucocorticoid on hemodynamics in patients resuscitated from out-of-hospital cardiac arrest: a sub-study of the STEROHCA trial
Following resuscitated out-of-hospital cardiac arrest (OHCA), inflammatory markers are significantly elevated and associated with hemodynamic instability and organ dysfunction. Vasopressor support is recommend...
Citation: Critical Care 2024 28:28 -
A comparison of video laryngoscopy and direct laryngoscopy in critically ill patients
Citation: Critical Care 2024 28:27 -
Enhanced exclusive enteral nutrition delivery during the first 7 days is associated with decreased 28-day mortality in critically ill patients with normal lactate level: a post hoc analysis of a multicenter randomized trial
Exclusive enteral nutrition (EN) is often observed during the first week of ICU admission because of the extra costs and safety considerations for early parenteral nutrition. This study aimed to assess the ass...
Citation: Critical Care 2024 28:26 -
Potential correlation between hemodynamic improvement and an immune-modulation effect in pediatric patients with septic shock treated with renal replacement therapy and CytoSorb®: an insight from the PedCyto study
Citation: Critical Care 2024 28:25 -
Association between urea trajectory and protein dose in critically ill adults: a secondary exploratory analysis of the effort protein trial (RE-EFFORT)
Delivering higher doses of protein to mechanically ventilated critically ill patients did not improve patient outcomes and may have caused harm. Longitudinal urea measurements could provide additional informat...
Citation: Critical Care 2024 28:24 -
The effect of passive leg raising test on intracranial pressure and cerebral autoregulation in brain injured patients: a physiological observational study
The use of the passive leg raising (PLR) is limited in acute brain injury (ABI) patients with increased intracranial pressure (ICP) since the postural change of the head may impact on ICP and cerebral autoregu...
Citation: Critical Care 2024 28:23 -
Rotten and gold apples: inside and outside the gray zone of a ROC curve
Citation: Critical Care 2024 28:22 -
The importance of assessing left ventricular longitudinal function in presence of increased afterload
Citation: Critical Care 2024 28:21 -
Combined effects of targeted blood pressure, oxygenation, and duration of device-based fever prevention after out-of-hospital cardiac arrest on 1-year survival: post hoc analysis of a randomized controlled trial
The “Blood Pressure and Oxygenation Targets in Post Resuscitation Care” (BOX) trial investigated whether a low versus high blood pressure target, a restrictive versus liberal oxygenation target, and a shorter ...
Citation: Critical Care 2024 28:20 -
Driving pressure of respiratory system and lung stress in mechanically ventilated patients with active breathing
During control mechanical ventilation (CMV), the driving pressure of the respiratory system (ΔPrs) serves as a surrogate of transpulmonary driving pressure (ΔPlung). Expiratory muscle activity that decreases end-...
Citation: Critical Care 2024 28:19 -
Gut mycobiome dysbiosis after sepsis and trauma
Sepsis and trauma are known to disrupt gut bacterial microbiome communities, but the impacts and perturbations in the fungal (mycobiome) community after severe infection or injury, particularly in patients exp...
Citation: Critical Care 2024 28:18
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- ISSN: 1364-8535 (electronic)