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  1. Research

    Hemoadsorption by CytoSorb in septic patients: a case series

    Septic shock, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, is a highly lethal condition that causes substantial morbidity and mortality among critically il...

    Klaus Kogelmann, Dominik Jarczak, Morten Scheller and Matthias Drüner

    Critical Care 2017 21:74

    Published on: 27 March 2017

  2. Research

    Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit

    The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) Task Force recently introduced a new clinical score termed quick Sequential (Sepsis-related) Organ Failure Assessment (qSOFA...

    Eli J. Finkelsztein, Daniel S. Jones, Kevin C. Ma, Maria A. Pabón, Tatiana Delgado, Kiichi Nakahira, John E. Arbo, David A. Berlin, Edward J. Schenck, Augustine M. K. Choi and Ilias I. Siempos

    Critical Care 2017 21:73

    Published on: 26 March 2017

  3. Research

    Diagnostic value of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for acute kidney injury: a meta-analysis

    Tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7), inducers of G1 cell cycle arrest, are two recently discovered good biomarkers for early diagnosis of acu...

    Hui-Miao Jia, Li-Feng Huang, Yue Zheng and Wen-Xiong Li

    Critical Care 2017 21:77

    Published on: 25 March 2017

  4. Research

    Time-dependent association of glucocorticoids with adverse outcome in community-acquired pneumonia: a 6-year prospective cohort study

    The hypothalamic-pituitary-adrenal stress axis plays a crucial role in community-acquired pneumonia (CAP), with high cortisol being associated with disease severity and corticosteroid treatment resulting in ea...

    Manuela Nickler, Manuel Ottiger, Christian Steuer, Alexander Kutz, Mirjam Christ-Crain, Werner Zimmerli, Robert Thomann, Claus Hoess, Christoph Henzen, Luca Bernasconi, Andreas Huber, Beat Mueller and Philipp Schuetz

    Critical Care 2017 21:72

    Published on: 24 March 2017

  5. Research

    Predictors of hospital and one-year mortality in intensive care patients with refractory status epilepticus: a population-based study

    The aim was to determine predictors of hospital and 1-year mortality in patients with intensive care unit (ICU)-treated refractory status epilepticus (RSE) in a population-based study.

    Anne-Mari Kantanen, Reetta Kälviäinen, Ilkka Parviainen, Marika Ala-Peijari, Tom Bäcklund, Juha Koskenkari, Ruut Laitio and Matti Reinikainen

    Critical Care 2017 21:71

    Published on: 23 March 2017

  6. Research

    Intestinal T lymphocyte homing is associated with gastric emptying and epithelial barrier function in critically ill: a prospective observational study

    Impaired gastric emptying is common in critically ill patients. Intestinal dysmotility, a major cause of feed intolerance, may foster infectious complications due to mucosal barrier disruption. However, little...

    Christian Greis, Zohal Rasuly, Rolf A. Janosi, Lambros Kordelas, Dietrich W. Beelen and Tobias Liebregts

    Critical Care 2017 21:70

    Published on: 22 March 2017

  7. Review

    Anti-inflammatory properties of anesthetic agents

    This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at

    Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco and Paolo Pelosi

    Critical Care 2017 21:67

    Published on: 21 March 2017

  8. Review

    Neuroanatomy of sepsis-associated encephalopathy

    This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at

    Nicholas Heming, Aurelien Mazeraud, Franck Verdonk, Fernando A. Bozza, Fabrice Chrétien and Tarek Sharshar

    Critical Care 2017 21:65

    Published on: 21 March 2017

  9. Research

    The association of time and medications with changes in bone mineral density in the 2 years after critical illness

    Critical illness is associated with increased risk of fragility fracture and loss of bone mineral density (BMD), although the impact of medication exposures (bone anti-fracture therapy or glucocorticoids) and ...

    Neil R. Orford, Michael Bailey, Rinaldo Bellomo, Julie A. Pasco, Claire Cattigan, Tania Elderkin, Sharon L. Brennan-Olsen, David J. Cooper and Mark A. Kotowicz

    Critical Care 2017 21:69

    Published on: 21 March 2017

  10. Review

    Facing the ongoing challenge of the febrile young infant

    This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at

    Adrienne G. DePorre, Paul L. Aronson and Russell J. McCulloh

    Critical Care 2017 21:68

    Published on: 21 March 2017

  11. Research

    Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis

    Inhibition of procoagulant pathways may improve outcome in sepsis. We examined whether a dual short-acting thrombin (factor II) and factor X (FX)a inhibitor (SATI) ameliorates sepsis-induced disseminated intra...

    Herbert Schöchl, Martijn van Griensven, Stefan Heitmeier, Volker Laux, Ulrike Kipman, Jan Roodt, Soheyl Bahrami and Heinz Redl

    Critical Care 2017 21:51

    Published on: 13 March 2017

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