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  1. Research

    Heat and moisture exchangers (HMEs) and heated humidifiers (HHs) in adult critically ill patients: a systematic review, meta-analysis and meta-regression of randomized controlled trials

    The aims of this systematic review and meta-analysis of randomized controlled trials are to evaluate the effects of active heated humidifiers (HHs) and moisture exchangers (HMEs) in preventing artificial airwa...

    Maria Vargas, Davide Chiumello, Yuda Sutherasan, Lorenzo Ball, Antonio M. Esquinas, Paolo Pelosi and Giuseppe Servillo

    Critical Care 2017 21:123

    Published on: 29 May 2017

  2. Research

    Circulating microparticle levels are reduced in patients with ARDS

    It is unclear how to identify which patients at risk for acute respiratory distress syndrome (ARDS) will develop this condition during critical illness. Elevated microparticle (MP) concentrations in the airspa...

    Ciara M. Shaver, Justin Woods, Jennifer K. Clune, Brandon S. Grove, Nancy E. Wickersham, J. Brennan McNeil, Gregory Shemancik, Lorraine B. Ware and Julie A. Bastarache

    Critical Care 2017 21:120

    Published on: 25 May 2017

  3. Research

    Comparison of fluid balance and hemodynamic and metabolic effects of sodium lactate versus sodium bicarbonate versus 0.9% NaCl in porcine endotoxic shock: a randomized, open-label, controlled study

    Sodium lactate has been shown to improve hemodynamics and avoid fluid overload. The objective of this study was to confirm a beneficial effect on fluid balance with sodium lactate infusion and to specify wheth...

    Thibault Duburcq, Arthur Durand, Anne-Frédérique Dessein, Joseph Vamecq, Jean-Claude Vienne, Dries Dobbelaere, Karine Mention, Claire Douillard, Patrice Maboudou, Valery Gmyr, François Pattou, Mercé Jourdain, Fabienne Tamion, Julien Poissy, Daniel Mathieu and Raphaël Favory

    Critical Care 2017 21:113

    Published on: 19 May 2017

  4. Research

    Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial

    Simvastatin therapy for patients with acute respiratory distress syndrome (ARDS) has been shown to be safe and associated with minimal adverse effects, but it does not improve clinical outcomes. The aim of thi...

    A. Agus, C. Hulme, R. M. Verghis, C. McDowell, C. Jackson, C. M. O’Kane, J. G. Laffey and D. F. McAuley

    Critical Care 2017 21:108

    Published on: 17 May 2017

  5. Research

    Cost analysis of the very elderly admitted to intensive care units

    Very elderly patients are often admitted to intensive care units (ICUs) despite poor outcomes and frequent preference to avoid unnecessary prolongation of life. We sought to determine the cost of ICU admission...

    Nicolas Chin-Yee, Gianni D’Egidio, Kednapa Thavorn, Daren Heyland and Kwadwo Kyeremanteng

    Critical Care 2017 21:109

    Published on: 16 May 2017

  6. Erratum

    Erratum to: Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions

    Cristóbal León, Sergio Ruiz-Santana, Pedro Saavedra, Carmen Castro, Ana Loza, Ismail Zakariya, Alejandro Úbeda, Manuel Parra, Desirée Macías, José Ignacio Tomás, Antonio Rezusta, Alejandro Rodríguez, Frederic Gómez and Estrella Martín-Mazuelos

    Critical Care 2017 21:107

    Published on: 15 May 2017

    The original article was published in Critical Care 2016 20:149

  7. Research

    Early EEG for outcome prediction of postanoxic coma: prospective cohort study with cost-minimization analysis

    We recently showed that electroencephalography (EEG) patterns within the first 24 hours robustly contribute to multimodal prediction of poor or good neurological outcome of comatose patients after cardiac arre...

    Lotte Sondag, Barry J. Ruijter, Marleen C. Tjepkema-Cloostermans, Albertus Beishuizen, Frank H. Bosch, Janine A. van Til, Michel J. A. M. van Putten and Jeannette Hofmeijer

    Critical Care 2017 21:111

    Published on: 15 May 2017

  8. Viewpoint

    High protein intake without concerns?

    The high fashion in nutrition for the critically ill is to recommend a high protein intake. Several opinion leaders are surfing on this wave, expanding the suggested protein allowance upwards. At the same time...

    Olav Rooyackers, Martin Sundström Rehal, Felix Liebau, Åke Norberg and Jan Wernerman

    Critical Care 2017 21:106

    Published on: 15 May 2017

  9. Research

    Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis

    A decrease in blood lactate levels (Lac) >10% during the first hours of resuscitation in sepsis is associated with better outcomes, but the mechanisms are unclear. Our objective was to investigate the relation...

    Thiago Domingos Corrêa, Adriano José Pereira, Sebastian Brandt, Madhusudanarao Vuda, Siamak Djafarzadeh, Jukka Takala and Stephan Mathias Jakob

    Critical Care 2017 21:105

    Published on: 12 May 2017

  10. Research

    Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study)

    Fluid therapy in severely malnourished children is hypothesized to be deleterious owing to compromised cardiac function. We evaluated World Health Organization (WHO) fluid resuscitation guidelines for hypovola...

    Nchafatso Obonyo, Bernadette Brent, Peter Olupot-Olupot, Michael Boele van Hensbroek, Irene Kuipers, Sidney Wong, Kenji Shiino, Jonathan Chan, John Fraser, Job B. M. van Woensel and Kathryn Maitland

    Critical Care 2017 21:103

    Published on: 3 May 2017

  11. Research

    Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia

    Metabolomics is a tool that has been used for the diagnosis and prognosis of specific diseases. The purpose of this study was to examine if metabolomics could be used as a potential diagnostic and prognostic t...

    Mohammad M. Banoei, Hans J. Vogel, Aalim M. Weljie, Anand Kumar, Sachin Yende, Derek C. Angus and Brent W. Winston

    Critical Care 2017 21:97

    Published on: 19 April 2017

  12. Review

    New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management

    Pharmacological and cellular treatment of cancer is changing dramatically with benefits for patient outcome and comfort, but also with new toxicity profiles. The majority of adverse events can be classified as...

    Frank Kroschinsky, Friedrich Stölzel, Simone von Bonin, Gernot Beutel, Matthias Kochanek, Michael Kiehl and Peter Schellongowski

    Critical Care 2017 21:89

    Published on: 14 April 2017

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