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  1. Research

    Decreased cytokine production by mononuclear cells after severe gram-negative infections: early clinical signs and association with final outcome

    Failure of circulating monocytes for adequate cytokine production is a trait of sepsis-induced immunosuppression; however, its duration and association with final outcome are poorly understood.

    Nikolaos Antonakos, Thomas Tsaganos, Volker Oberle, Iraklis Tsangaris, Malvina Lada, Aikaterini Pistiki, Nikolaos Machairas, Maria Souli, Michael Bauer and Evangelos J. Giamarellos-Bourboulis

    Critical Care 2017 21:48

    Published on: 9 March 2017

  2. Research

    Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock

    Acute kidney injury (AKI) is a multifactorial syndrome, but knowledge about its pathophysiology and possible genetic background is limited. Recently the first hypothesis-free genetic association studies have b...

    Laura M. Vilander, Mari A. Kaunisto, Suvi T. Vaara and Ville Pettilä

    Critical Care 2017 21:47

    Published on: 8 March 2017

  3. Research

    Evaluation of clinically available renal biomarkers in critically ill adults: a prospective multicenter observational study

    Although serum cystatin C (sCysC), urinary N-acetyl-β-d-glucosaminidase (uNAG), and urinary albumin/creatinine ratio (uACR) are clinically available, their optimal combination for acute kidney injury (AKI) detect...

    Yujun Deng, Ruibin Chi, Shenglong Chen, Heng Ye, Jie Yuan, Lin Wang, Yiling Zhai, Lu Gao, Danqing Zhang, Linhui Hu, Bo Lv, Yi Long, Cheng Sun, Xiaobing Yang, Xia Zou and Chunbo Chen

    Critical Care 2017 21:46

    Published on: 7 March 2017

  4. Research

    Duration of veno-arterial extracorporeal life support (VA ECMO) and outcome: an analysis of the Extracorporeal Life Support Organization (ELSO) registry

    Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is an effective rescue therapy for severe cardiorespiratory failure, but morbidity and mortality are high. We hypothesised that survival decreases wi...

    Myles Smith, Alexander Vukomanovic, Daniel Brodie, Ravi Thiagarajan, Peter Rycus and Hergen Buscher

    Critical Care 2017 21:45

    Published on: 6 March 2017

  5. Research

    The accuracy of transcranial Doppler in excluding intracranial hypertension following acute brain injury: a multicenter prospective pilot study

    Untimely diagnosis of intracranial hypertension may lead to delays in therapy and worsening of outcome. Transcranial Doppler (TCD) detects variations in cerebral blood flow velocity which may correlate with in...

    Frank A. Rasulo, Rita Bertuetti, Chiara Robba, Francesco Lusenti, Alfredo Cantoni, Marta Bernini, Alan Girardini, Stefano Calza, Simone Piva, Nazzareno Fagoni and Nicola Latronico

    Critical Care 2017 21:44

    Published on: 27 February 2017

  6. Research

    Clonidine for sedation in the critically ill: a systematic review and meta-analysis

    This systematic review and meta-analysis investigates the efficacy and safety of clonidine as a sedative in critically ill patients requiring invasive mechanical ventilation.

    Jing Gennie Wang, Emilie Belley-Coté, Lisa Burry, Mark Duffett, Timothy Karachi, Dan Perri, Waleed Alhazzani, Frederick D’Aragon, Hannah Wunsch and Bram Rochwerg

    Critical Care 2017 21:75

    Published on: 25 February 2017

  7. Research

    SOFA and mortality endpoints in randomized controlled trials: a systematic review and meta-regression analysis

    The sequential organ failure assessment score (SOFA) is increasingly used as an endpoint in intensive care randomized controlled trials (RCTs). Although serially measured SOFA is independently associated with ...

    Harm-Jan de Grooth, Irma L. Geenen, Armand R. Girbes, Jean-Louis Vincent, Jean-Jacques Parienti and Heleen M. Oudemans-van Straaten

    Critical Care 2017 21:38

    Published on: 24 February 2017

  8. Research

    Catecholamines as outcome markers in isolated traumatic brain injury: the COMA-TBI study

    Elevated catecholamine levels might be associated with unfavorable outcome after traumatic brain injury (TBI). We investigated the association between catecholamine levels in the first 24 h post-trauma and fun...

    Sandro B. Rizoli, Blessing N. R. Jaja, Alex P. Di Battista, Shawn G. Rhind, Antonio Capone Neto, Leodante da Costa, Kenji Inaba, Luis Teodoro da Luz, Bartolomeu Nascimento, Adic Perez, Andrew J. Baker and Airton Leonardo de Oliveira Manoel

    Critical Care 2017 21:37

    Published on: 23 February 2017

  9. Research

    Can body mass index predict clinical outcomes for patients with acute lung injury/acute respiratory distress syndrome? A meta-analysis

    The effects of body mass index (BMI) on the prognosis of acute respiratory distress syndrome (ARDS) are controversial. We aimed to further determine the relationship between BMI and the acute outcomes of patie...

    Yue-Nan Ni, Jian Luo, He Yu, Yi-Wei Wang, Yue-Hong Hu, Dan Liu, Bin-Miao Liang and Zong-An Liang

    Critical Care 2017 21:36

    Published on: 22 February 2017

  10. Research

    Noninvasive detection of alarming intracranial pressure changes by auditory monitoring in early management of brain injury: a prospective invasive versus noninvasive study

    In brain-injured patients intracranial pressure (ICP) is monitored invasively by a ventricular or intraparenchymal transducer. The procedure requires specific expertise and exposes the patient to complications...

    Fabrice Giraudet, François Longeras, Aurélien Mulliez, Aurélie Thalamy, Bruno Pereira, Paul Avan and Laurent Sakka

    Critical Care 2017 21:35

    Published on: 21 February 2017

  11. Research

    The impact of post-operative sepsis on mortality after hospital discharge among elective surgical patients: a population-based cohort study

    Our aim in the present study was to assess the mortality impact of hospital-acquired post-operative sepsis up to 1 year after hospital discharge among adult non-short-stay elective surgical patients.

    Lixin Ou, Jack Chen, Ken Hillman, Arthas Flabouris, Michael Parr, Hassan Assareh and Rinaldo Bellomo

    Critical Care 2017 21:34

    Published on: 20 February 2017

  12. Research

    Use of stepwise lactate kinetics-oriented hemodynamic therapy could improve the clinical outcomes of patients with sepsis-associated hyperlactatemia

    Setting lactate kinetics at >30% might improve the clinical outcomes of patients with sepsis-associated hyperlactatemia. The aim of this study was to explore the outcome benefits of stepwise lactate kinetics v...

    Xiang Zhou, Dawei Liu, Longxiang Su, Bo Yao, Yun Long, Xiaoting Wang, Wenzhao Chai, Na Cui, Hao Wang and Xi Rui

    Critical Care 2017 21:33

    Published on: 16 February 2017

  13. Research

    Point-of-care testing for emergency assessment of coagulation in patients treated with direct oral anticoagulants

    Point-of-care testing (POCT) of coagulation has been proven to be of great value in accelerating emergency treatment. Specific POCT for direct oral anticoagulants (DOAC) is not available, but the effects of DO...

    Matthias Ebner, Ingvild Birschmann, Andreas Peter, Charlotte Spencer, Florian Härtig, Joachim Kuhn, Gunnar Blumenstock, Christine S. Zuern, Ulf Ziemann and Sven Poli

    Critical Care 2017 21:32

    Published on: 15 February 2017

  14. Letter

    Blood pressure and acute kidney injury

    Maintaining the optimal blood pressure is an important aspect of preventing acute kidney injury (AKI), especially for vasopressor-dependent patients. Although mean arterial pressure (MAP) has played an importa...

    Ryota Sato, Sarah Kyuragi Luthe and Michitaka Nasu

    Critical Care 2017 21:28

    Published on: 10 February 2017

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