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  1. Research

    Predictors of hospital and one-year mortality in intensive care patients with refractory status epilepticus: a population-based study

    The aim was to determine predictors of hospital and 1-year mortality in patients with intensive care unit (ICU)-treated refractory status epilepticus (RSE) in a population-based study.

    Anne-Mari Kantanen, Reetta Kälviäinen, Ilkka Parviainen, Marika Ala-Peijari, Tom Bäcklund, Juha Koskenkari, Ruut Laitio and Matti Reinikainen

    Critical Care 2017 21:71

    Published on: 23 March 2017

  2. Research

    Intestinal T lymphocyte homing is associated with gastric emptying and epithelial barrier function in critically ill: a prospective observational study

    Impaired gastric emptying is common in critically ill patients. Intestinal dysmotility, a major cause of feed intolerance, may foster infectious complications due to mucosal barrier disruption. However, little...

    Christian Greis, Zohal Rasuly, Rolf A. Janosi, Lambros Kordelas, Dietrich W. Beelen and Tobias Liebregts

    Critical Care 2017 21:70

    Published on: 22 March 2017

  3. Review

    Anti-inflammatory properties of anesthetic agents

    This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at

    Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco and Paolo Pelosi

    Critical Care 2017 21:67

    Published on: 21 March 2017

  4. Review

    Neuroanatomy of sepsis-associated encephalopathy

    This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at

    Nicholas Heming, Aurelien Mazeraud, Franck Verdonk, Fernando A. Bozza, Fabrice Chrétien and Tarek Sharshar

    Critical Care 2017 21:65

    Published on: 21 March 2017

  5. Research

    The association of time and medications with changes in bone mineral density in the 2 years after critical illness

    Critical illness is associated with increased risk of fragility fracture and loss of bone mineral density (BMD), although the impact of medication exposures (bone anti-fracture therapy or glucocorticoids) and ...

    Neil R. Orford, Michael Bailey, Rinaldo Bellomo, Julie A. Pasco, Claire Cattigan, Tania Elderkin, Sharon L. Brennan-Olsen, David J. Cooper and Mark A. Kotowicz

    Critical Care 2017 21:69

    Published on: 21 March 2017

  6. Review

    Facing the ongoing challenge of the febrile young infant

    This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2017. Other selected articles can be found online at

    Adrienne G. DePorre, Paul L. Aronson and Russell J. McCulloh

    Critical Care 2017 21:68

    Published on: 21 March 2017

  7. Research

    Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis

    Inhibition of procoagulant pathways may improve outcome in sepsis. We examined whether a dual short-acting thrombin (factor II) and factor X (FX)a inhibitor (SATI) ameliorates sepsis-induced disseminated intra...

    Herbert Schöchl, Martijn van Griensven, Stefan Heitmeier, Volker Laux, Ulrike Kipman, Jan Roodt, Soheyl Bahrami and Heinz Redl

    Critical Care 2017 21:51

    Published on: 13 March 2017

  8. Research

    Decreased cytokine production by mononuclear cells after severe gram-negative infections: early clinical signs and association with final outcome

    Failure of circulating monocytes for adequate cytokine production is a trait of sepsis-induced immunosuppression; however, its duration and association with final outcome are poorly understood.

    Nikolaos Antonakos, Thomas Tsaganos, Volker Oberle, Iraklis Tsangaris, Malvina Lada, Aikaterini Pistiki, Nikolaos Machairas, Maria Souli, Michael Bauer and Evangelos J. Giamarellos-Bourboulis

    Critical Care 2017 21:48

    Published on: 9 March 2017

  9. Research

    Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock

    Acute kidney injury (AKI) is a multifactorial syndrome, but knowledge about its pathophysiology and possible genetic background is limited. Recently the first hypothesis-free genetic association studies have b...

    Laura M. Vilander, Mari A. Kaunisto, Suvi T. Vaara and Ville Pettilä

    Critical Care 2017 21:47

    Published on: 8 March 2017

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