Volume 1 Supplement 1
Intermittent hemodiafiltration rapidly decreases serum myoglobin levels in rhabdomyolysis
© Current Science Ltd 1997
Published: 1 March 1997
Myoglobin is a pigment protein (MW 17800 D), which forms hematin if tubular pH is low and may cause acute renal failure (ARF). Aggressive fluid therapy, alkalinization of the urine, loop diuretics and mannitol are used in prevention of ARF with varying success. CAVH decreases serum myoglobin levels , but is not routinely used. Regardless of the therapy of rhabdomyolysis, the mortality of associated ARF remains high, approximately 30% . The aim of this study was to examine the effect of intermittent 4-h hemodiafiltration (HDF) on serum myoglobin levels.
HDF was done using predilution technique with AK 100 Ultra equipment, Polyflux 17 hemodiafilter and BiCart 205 acid sodium bicarbonate concentrate (Gambro, Sweden)
Ultrafiltration rate was 167 ml/min, dialysis fluid rate was 333 ml/min and blood pump rate was 250 ml/min. The filtrated fluid was substituted by on-line system of the equipment.
- Winterberg B, Ramme K, Tenschert W, et al: Hemofiltration in myoglobinuric acute renal failure. Int J Artif Organs. 1990, 13: 113-116.PubMedGoogle Scholar
- McCarthy JT: Prognosis of patients with acute renal failure in intensive-care unit. Mayo Clin Proc. 1996, 71: 117-126.PubMedView ArticleGoogle Scholar