Esophageal Doppler-guided fluid management decreases blood lactate levels in multiple-trauma patients: a randomized controlled trial
© Chytra et al.; licensee BioMed Central Ltd. 2007
Received: 23 October 2006
Accepted: 22 February 2007
Published: 22 February 2007
Esophageal Doppler was confirmed as a useful non-invasive tool for management of fluid replacement in elective surgery. The aim of this study was to assess the effect of early optimization of intravascular volume using esophageal Doppler on blood lactate levels and organ dysfunction development in comparison with standard hemodynamic management in multiple-trauma patients.
This was a randomized controlled trial. Multiple-trauma patients with blood loss of more than 2,000 ml admitted to the intensive care unit (ICU) were randomly assigned to the protocol group with esophageal Doppler monitoring and to the control group. Fluid resuscitation in the Doppler group was guided for the first 12 hours of ICU stay according to the protocol based on data obtained by esophageal Doppler, whereas control patients were managed conventionally. Blood lactate levels and organ dysfunction during ICU stay were evaluated.
Eighty patients were randomly assigned to Doppler and 82 patients to control treatment. The Doppler group received more intravenous colloid during the first 12 hours of ICU stay (1,667 ± 426 ml versus 682 ± 322 ml; p < 0.0001), and blood lactate levels in the Doppler group were lower after 12 and 24 hours of treatment than in the control group (2.92 ± 0.54 mmol/l versus 3.23 ± 0.54 mmol/l [p = 0.0003] and 1.99 ± 0.44 mmol/l versus 2.37 ± 0.58 mmol/l [p < 0.0001], respectively). No difference in organ dysfunction between the groups was found. Fewer patients in the Doppler group developed infectious complications (15 [18.8%] versus 28 [34.1%]; relative risk = 0.5491; 95% confidence interval = 0.3180 to 0.9482; p = 0.032). ICU stay in the Doppler group was reduced from a median of 8.5 days (interquartile range [IQR] 6 to16) to 7 days (IQR 6 to 11) (p = 0.031), and hospital stay was decreased from a median of 17.5 days (IQR 11 to 29) to 14 days (IQR 8.25 to 21) (p = 0.045). No significant difference in ICU and hospital mortalities between the groups was found.
Optimization of intravascular volume using esophageal Doppler in multiple-trauma patients is associated with a decrease of blood lactate levels, a lower incidence of infectious complications, and a reduced duration of ICU and hospital stays.
Post-traumatic hemorrhage in multiple-trauma patients leads to hypovolemia, in which blood flow and consequently oxygen delivery to the tissues are decreased. Reduction of oxygen delivery and oxygen consumption to below a critical level produces ischemic metabolic insufficiency followed by increased generation of lactate [1–4]. Blood lactate levels are closely related to outcome in critically ill trauma patients [4–9], and failure of serum lactate levels to reach normal values within a specific time during critical illness could be even more closely related to survival than the initial level [10–15]. According to a systematic Medicine/Cochrane Library literature search, blood lactate level was shown to predict outcome in almost 3,000 multiple-trauma patients .
Fluid resuscitation of trauma patients has traditionally been guided by the normalization of vital signs such as blood pressure, heart rate, and urine output. However, blood pressure and heart rate remain relatively unchanged despite reduced blood flow to certain tissues and hence they are insensitive indicators of hypovolemia and hypoperfusion [14, 16–18]. Occult hypoperfusion, defined as elevated blood lactate levels without signs of clinical shock, was associated with increased morbidity and mortality, and early correction is likely to improve the outcome [7, 8, 10, 19].
The esophageal Doppler is a non-invasive technique for monitoring cardiac function in intensive care unit (ICU) patients. The technique and clinical use were first described in 1971 , subsequently refined by Singer and colleagues in 1989 , and recently have been successfully approved for optimizing fluid management perioperatively and in intensive care patients [22–29]. Unfortunately, the Doppler probe is not readily tolerated by conscious patients, restricting its use to patients who are sedated and ventilated. To our knowledge, no prospective study has been performed to assess the efficacy of the esophageal Doppler for optimization of fluid management in multiple-trauma patients in the immediate postoperative period.
The aim of this study was to examine the effect of esophageal Doppler-guided fluid management during the first 12 hours after ICU admission on blood lactate levels, organ dysfunction development, infectious complications, and length of ICU and hospital stays in comparison with standard hemodynamic management in multiple-trauma patients.
Materials and methods
This was a randomized, controlled, single-center study conducted in the interdisciplinary ICU of a university teaching hospital. The study was approved by the Local Research Ethics Committee of University Hospital in Plzeň (Czech Republic). Because the protocol was approved and regarded as part of the routine practice and (due to the emergency clause) informed consent by the patients or the family was not required, an independent physician was designated to give the consent. However, subjects were informed at discharge that they had participated in this clinical study.
Ventilated patients with multiple trauma and estimated blood loss of more than 2,000 ml admitted to the interdisciplinary ICU of our university teaching hospital from 2003 to 2005 were considered for inclusion in this study. We excluded patients younger than 18 years old, patients with traumatic brain injury requiring treatment of intracranial hypertension, and those with relative contraindications to the use of the esophageal Doppler probe, such as orofacial and esophageal injury or other known oropharyngeal and esophageal disease.
Primary outcome measures were blood lactate levels after 12 and 24 hours after ICU admission and organ dysfunction development during ICU stay. Secondary outcome measures were duration of ICU and hospital stays and the incidence of infectious complications during ICU stay.
Patients with multiple trauma were initially examined and treated in the emergency department of the university teaching hospital and after urgent surgery were admitted to the ICU. The amount of blood loss in the pre-study period was estimated by an emergency department physician and by an anesthesiologist taking care of the screened patient. Neither of them was a member of the research team. At the time of ICU admission and during the first 12 hours of ICU stay, all patients were mechanically ventilated (pressure-controlled ventilation) and received adequate continuous analgosedation (fentanyl + midazolam) to keep the Ramsay Scale score between 4 and 5 .
All patients were managed to maintain hemoglobin oxygen saturation (measured using pulse oximetry) above 95%, mean arterial pressure (MAP) above 65 mm Hg, heart rate below 100 bpm, urine output above 1 ml/kg per hour, temperature at 37°C, and hemoglobin above 85 g/l. Anemia and coagulation disorders in all patients were treated by administration of erythrocytes, platelets, and fresh frozen plasma (FFP) according to clinical and laboratory results. All patients received basic crystalloid infusion of 1.5 ml/kg per hour (Hartman's solution; B. Braun Melsungen AG, Melsungen, Germany). When necessary, norepinephrine was added to keep MAP above 65 mm Hg. Further plasma volume replacement in the Doppler and control groups was managed by colloid solutions administration of gelatine and hydroxyethylstarch in a 1:1 ratio (Gelofusine®; B. Braun Melsungen AG, and Voluven®; Fresenius Kabi AG, Bad Homburg, Germany). Fluid management in the control group was guided using the abovementioned routine cardiovascular monitoring and central venous pressure (CVP) measurement in order to keep CVP between 12 and 15 mm Hg.
The following parameters were monitored during the study period: electrocardiograph, pulse oximetry, invasive arterial pressure, CVP, urine output, and (in the Doppler group) SV and FTc. Acute Physiology and Chronic Health Evaluation II (APACHE II) score and Injury Severity Score (ISS) were calculated after admission to the ICU. Sequential Organ Failure Assessment (SOFA) score was calculated daily, and the values at the time of ICU admission and the highest SOFA during ICU stay were assessed. MAP and CVP were evaluated at baseline and at the end of the 12-hour study period. Blood lactate levels were assessed at baseline and 12 and 24 hours after ICU admission. The normal value of blood lactate in our laboratory is less than 2.4 mmol/l. Rate and dose of norepinephrine, volume of administered crystalloids and colloids, and blood and FFP during the first 12 hours of the study period were assessed. Length of ICU and hospital stays, ICU and hospital mortalities, and incidence of infectious complications during ICU stay were evaluated. Diagnosis of infectious complications was established by non-research staff in accordance with predefined criteria . Patients were followed up to hospital discharge.
For the measure of primary outcome with reference to previous studies and our pilot data [13, 15, 34, 35], we calculated a study size of 75 patients in each group to demonstrate the decrease of blood lactate levels by 0.6 mmol/l per 24 hours (standard deviation [SD] ± 1.3) in the Doppler group in comparison with the control group. For the measure of secondary outcome with reference to previous data , we calculated a sample size of 160 patients (80 in each group) by postulating a reduction in mean ICU stay from nine days in the control group to seven days in the protocol group (SD ± 4.5). Sample sizes were calculated for two-tailed tests allowing for a type I error of 5% and a type II error of 20%. The Kolmogorov-Smirnov test was used to check for normal distribution of data. Continuous normally distributed data were tested with the t test, and not normally distributed data were tested with the Mann-Whitney U test. Categorical data were tested with the Fisher exact test. Data are presented as means (SDs) where normally distributed and as medians (interquartile ranges) where not normally distributed. Relative risk is presented with 95% confidence intervals (CIs). A p value of less than 0.05 was considered statistically significant. Analysis was performed with MedCalc® version 22.214.171.124 (Frank Schoonjans, MedCalc Software, Broekstraat 52, 9030 Mariakerke, Belgium).
Baseline characteristics of patients in the Doppler and control groups
Number in group
Age in years
Injury Severity Score
38.5 ± 10.5
36.4 ± 11.8
SOFA score at ICU admission
Type of injury
Baseline parameters and therapeutic interventions
Doppler group (n = 80)
Control group (n = 82)
Mean arterial pressure (mm Hg)
Central venous pressure (mm Hg)
7.1 ± 2.1
6.8 ± 2.1
Norepinephrine (μg/kg per minute)
Therapeutic interventions and changes in parameters during the 12-hour study period
Doppler group (n = 80)
Control group (n = 82)
Mean arterial pressure (mm Hg)
78 ± 6.5
79 ± 9.5
Central venous pressure (mm Hg)
13.7 ± 1.8
12.1 ± 2.4
2.92 ± 0.54
3.23 ± 0.54
1,667 ± 426
682 ± 322
1,293 ± 300
1,334 ± 320
814 ± 228
833 ± 340
Fresh frozen plasma (ml)
Norepinephrine (μg/kg per minute)
0.093 ± 0.035
0.169 ± 0.068
Summary of outcomes after the 12-hour intervention period
Doppler group (n = 80)
Control group (n = 82)
Lactate after 24 hours of ICU stay (mmol/l)
1.99 ± 0.44
2.37 ± 0.59
The highest SOFA during ICU stay
Central venous catheter
Total infectious complications
Patients with infectious complications
Length of ICU stay in days
Length of hospital stay in days
Esophageal Doppler-guided fluid management in multiple-trauma patients decreased blood lactate levels, lowered the incidence of infectious complications, and reduced the length of ICU and hospital stays. Occult tissue hypoperfusion in trauma patients is relatively common and cannot be diagnosed and eliminated using traditional markers and resuscitation endpoints (blood pressure, heart rate, and urine output). Scalea and colleagues  found that up to 80% of critically ill patients who are normotensive and have adequate urine output may remain in a state of compensated shock. One of most commonly used markers in assessing occult tissue hypoperfusion in trauma patients is blood lactate. Several studies have shown that normalization of blood lactate levels within 24 hours of admission in hemodynamically stable trauma patients was associated with improved survival, less frequent infection rate, and organ dysfunction development [7, 8, 10–12]. Persistent elevated lactate levels 24 hours after admission significantly correlated with mortality . Limited prospective data are available, but these indicate that rapid normalization of increased blood lactate levels is an important therapeutic goal in critically ill patients . Adequate fluid resuscitation to increase cardiac output has been found to improve tissue oxygen delivery in patients with tissue hypoxia and remains the mainstay of therapy in these circumstances . Esophageal Doppler flowmetry used to maximize intraoperative SV by repeated fluid challenges was associated with improved outcome and reductions in length of hospital stay after cardiac, orthopedic, or abdominal surgery [22–25, 28]. Our data are in agreement with other studies [19, 26, 36] and support the statement that some beneficial effects might still be achieved from optimization of circulatory status in the immediate postoperative period.
Although decreased blood lactate levels in Doppler group patients during the first 12 and 24 hours of ICU stay indicate improved tissue perfusion and oxygenation, surprisingly we did not prove a significant difference between the Doppler and control groups in organ failure development during ICU stay. Presumably, the difference in tissue oxygen delivery in both groups was not significant enough to induce organ-function changes measurable by SOFA score. With reference to the 'golden hour' and the 'silver day' of trauma resuscitation [10, 37], a partial explanation for this finding can be that despite the higher blood lactate levels in control group patients, oxygen delivery in both groups was sufficient to achieve normal lactate levels within 24 hours of ICU stay. However, other factors that could help to explain the uniformity in levels of organ dysfunction and mortality between the protocol and control groups (that is, amount of time elapsed between the injury and emergency department admission, duration of surgery, and amount of blood transfused before ICU admission) were not analyzed.
A relationship between the rapid normalization of blood lactate level and the lower rate of infectious complications in trauma patients was clearly demonstrated [7, 8, 10, 36]. The blood lactate level in the control group after 12 and 24 hours of study was higher than in the Doppler group, and even though the blood lactate level after 24 hours of ICU stay in both groups reached the normal range, more patients in the control group developed infectious complications during ICU stay. Clinical studies support the notion that adequate fluid resuscitation may improve tissue oxygen tension and decrease the rate of complications [22, 38]. Other studies have demonstrated that inadequate tissue perfusion measured with gastric tonometry is associated with adverse perioperative outcome [39, 40]. Possibly, better tissue oxygenation results in improved tissue healing and decreased infection rate.
The use of esophageal Doppler for hemodynamic optimization based on administering fluids to achieve maximal left ventricular SV was associated with important reductions of ICU or hospital stay [22–26]. In the present study, esophageal Doppler-guided fluid management was associated with a 1.5-day median reduction in ICU stay and a 3.5-day median decrease in hospital stay. This suggests that optimization of circulatory status may also have financial implications and reduce the cost of care for multiple-trauma patients.
In a meta-analysis of hemodynamic optimization studies, Poeze and coworkers  showed that the use of strategies to optimize the hemodynamic condition perioperatively and during trauma significantly reduced mortality. In the present study, there was no statistical difference in ICU and hospital mortalities between the groups, and the study was not powered to show any difference in mortality. This would have required more than 700 patients.
There are some potential weaknesses in the design of our trial. It was of relatively small size, was not blinded, and was conducted in only one center. All patients in the control group received intravenous resuscitation guided by CVP measurement in order to keep CVP between 12 and 15 mmHg. However, because no reliable correlation between intravascular volume and absolute CVP measurement has been established, rather than apply an absolute target for CVP, dynamic changes of CVP to fluid challenge would likely provide a more reliable guide to fluid requirements [24, 36]. Recruitment of patients was possible only when a member of the research team was available to administer the 12-hour study protocol. During the trial period, 539 multiple-trauma patients were admitted to the ICU and mortality was 22.4% (including deaths within 24 hours after ICU admission).
The application of the 12-hour study protocol in the Doppler group was time-consuming and would not have been feasible without the close cooperation of the nursing staff. The continuous presence of a clinician at bedside for a 12-hour period is not realistic and thus the fluid challenge according to the Doppler-guided protocol was given partly by trained nursing staff. Whenever the quality of the Doppler signal was altered (due mostly to a change of probe position resulting from nurse or patient movement), a member of the research team was called and the probe was restored to the proper position. In spite of adequate sedation, it was difficult to keep the Doppler probe in the right position for 12 hours without frequent adjustments. We suppose that the use of other relatively non-invasive devices that measure SV and cardiac output (for example, cardiac output measurement using partial carbon dioxide rebreathing, thoracic impedance, and technologies using arterial pressure waveform analysis) may be less demanding for postoperative fluid and hemodynamic optimization. Moreover, these methods do not require deep sedation, can be used for longer periods, and do not discriminate patients who are not suitable for esophageal Doppler monitoring.
Optimization of intravascular volume using esophageal Doppler in multiple-trauma patients is associated with a decrease of blood lactate levels, a lower incidence of infectious complications, and a reduced duration of ICU and hospital stays. A large multicenter study should be performed to validate these findings and to demonstrate an effect on mortality.
Optimization of intravascular volume using esophageal Doppler in multiple-trauma patients decreases blood lactate levels.
Fluid resuscitation in multiple-trauma patients guided by esophageal Doppler is associated with a lower incidence of infectious complications and reduces ICU and hospital stays.
- APACHE II:
APACHE II = Acute Physiology and Chronic Health Evaluation II
CI = confidence interval
CVP = central venous pressure
FFP = fresh frozen plasma
FTc = flow time corrected
ICU = intensive care unit
ISS = Injury Severity Score
MAP = mean arterial pressure
SD = standard deviation
SOFA = Sequential Organ Failure Assessment
SV = stroke volume.
The study was supported by a research grant (IGA MZ CR ND/7712-3) and by the Czech Ministry of Education (project MSM0021620819).
- Rackow EC, Weil MH: Physiology of blood flow and oxygen utilization by peripheral tissue in circulatory shock. Clin Chem 1990, 36: 1544-1546.PubMedGoogle Scholar
- American College of Surgeons: Shock. In Advanced Trauma Life Support Manual. 6th edition. Chicago, IL;
- Manikis P, Jankowski S, Zhang H, Kahn RJ, Vincent JL: Correlation of serial blood lactate levels to organ failure and mortality after trauma. Am J Emerg Med 1995, 13: 619-622. 10.1016/0735-6757(95)90043-8View ArticlePubMedGoogle Scholar
- Rixen D, Siegel JH: Bench-to-bedside review: oxygen debt and its metabolic correlates as quantifiers of the severity of hemorrhagic and post-traumatic shock. Crit Care 2005, 9: 441-453. 10.1186/cc3526PubMed CentralView ArticlePubMedGoogle Scholar
- Regel G, Grotz M, Weltner T, Sturm JA, Tscherne H: Pattern of organ failure following severe trauma. World J Surg 1996, 20: 422-429. 10.1007/s002689900067View ArticlePubMedGoogle Scholar
- Sauaia A, Moore FA, Moore EE, Norris JM, Lezotte DC, Hamman RF: Multiple organ failure can be predicted as early as 12 hours after injury. J Trauma 1998, 45: 291-301.View ArticlePubMedGoogle Scholar
- Claridge JA, Crabtree TD, Pelletier SJ, Butler K, Sawyer RG, Young JS: Persistent occult hypoperfusion is associated with a significant increase in infection rate and mortality in major trauma patients. J Trauma 2000, 48: 8-14.View ArticlePubMedGoogle Scholar
- Crowl AC, Young JS, Kahler DM, Claridge JA, Chrzanowski DS, Pomphrey M: Occult hypoperfusion is associated with increased morbidity in patients undergoing early femur fracture fixation. J Trauma 2000, 48: 260-267.View ArticlePubMedGoogle Scholar
- Cerovic O, Golubovic V, Spec-Marn A, Kremzar B, Vidmar G: Relationship between injury severity and lactate levels in severely injured patients. Intensive Care Med 2003, 29: 1300-1305. 10.1007/s00134-003-1753-8View ArticlePubMedGoogle Scholar
- Blow O, Magliore L, Claridge JA, Butler K, Young JS: The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. J Trauma 1999, 47: 964-969.View ArticlePubMedGoogle Scholar
- McNelis J, Marini CP, Jurkiewicz A, Szomstein S, Simms HH, Ritter G, Nathan IM: Prolonged lactate clearance is associated with increased mortality in the surgical intensive care unit. Am J Surg 2001, 182: 481-485. 10.1016/S0002-9610(01)00755-3View ArticlePubMedGoogle Scholar
- Abramson D, Scalea TM, Hitchcock R, Trooskin SZ, Henry SM, Greenspan J: Lactate clearance and survival following injury. J Trauma 1993, 35: 584-588.View ArticlePubMedGoogle Scholar
- Husain FA, Martin MJ, Mullenix PS, Steele SR, Elliott DC: Serum lactate and base deficit as predictors of mortality and morbidity. Am J Surg 2003, 185: 485-491. 10.1016/S0002-9610(03)00044-8View ArticlePubMedGoogle Scholar
- Meregalli A, Oliveira RP, Friedman G: Occult hypoperfusion is associated with increased mortality in hemodynamically stable, high-risk, surgical patients. Crit Care 2004, 8: R60-65. 10.1186/cc2423PubMed CentralView ArticlePubMedGoogle Scholar
- Smith I, Kumar P, Molloy S, Rhodes A, Newman PJ, Grounds RM, Bennett ED: Base excess and lactate as prognostic indicators for patients admitted to intensive care. Intensive Care Med 2001, 27: 74-83. 10.1007/s001340051352View ArticlePubMedGoogle Scholar
- Scalea TM, Maltz S, Yelon J, Trooskin SZ, Duncan AO, Sclafani SJ: Resuscitation of multiple trauma and head injury: role of crystalloid fluids and inotropes. Crit Care Med 1994, 22: 1610-1615.View ArticlePubMedGoogle Scholar
- Abou-Khalil B, Scalea TM, Trooskin SZ, Henry SM, Hitchcock R: Hemodynamic responses to shock in young trauma patients: need for invasive monitoring. Crit Care Med 1994, 22: 633-639. 10.1097/00003246-199404000-00020View ArticlePubMedGoogle Scholar
- Wo CC, Shoemaker WC, Appel PL, Bishop MH, Kram HB, Hardin E: Unreliability of blood pressure and heart rate to evaluate cardiac output in emergency resuscitation and critical illness. Crit Care Med 1993, 21: 218-223. 10.1097/00003246-199302000-00012View ArticlePubMedGoogle Scholar
- Polonen P, Ruokonen E, Hippelainen M, Poyhonen M, Takala J: A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients. Anesth Analg 2000, 90: 1052-1059. 10.1097/00000539-200005000-00010View ArticlePubMedGoogle Scholar
- Side CD, Gosling RG: Non-surgical assessment of cardiac function. Nature 1971, 232: 335-336. 10.1038/232335a0View ArticlePubMedGoogle Scholar
- Singer M, Clarke J, Bennett ED: Continuous hemodynamic monitoring by esophageal Doppler. Crit Care Med 1989, 17: 447-452.View ArticlePubMedGoogle Scholar
- Mythen MG, Webb AR: Perioperative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion during cardiac surgery. Arch Surg 1995, 130: 423-429.View ArticlePubMedGoogle Scholar
- Sinclair S, James S, Singer M: Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial. BMJ 1997, 315: 909-912.PubMed CentralView ArticlePubMedGoogle Scholar
- Venn R, Steele A, Richardson P, Poloniecki J, Grounds M, Newman P: Randomized controlled trial to investigate influence of the fluid challenge on duration of hospital stay and perioperative morbidity in patients with hip fractures. Br J Anaesth 2002, 88: 65-71. 10.1093/bja/88.1.65View ArticlePubMedGoogle Scholar
- Gan TJ, Soppitt A, Maroof M, el-Moalem H, Robertson KM, Moretti E, Dwane P, Glass PS: Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery. Anesthesiology 2002, 97: 820-826. 10.1097/00000542-200210000-00012View ArticlePubMedGoogle Scholar
- McKendry M, McGloin H, Saberi D, Caudwell L, Brady AR, Singer M: Randomised controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiac surgery. BMJ 2004, 329: 258-261. 10.1136/bmj.38156.767118.7CPubMed CentralView ArticlePubMedGoogle Scholar
- Singer M, Bennet ED: Noninvasive optimization of left ventricular filling using esophageal Doppler. Crit Care Med 1991, 19: 1132-1137.View ArticlePubMedGoogle Scholar
- Wakeling HG, McFall MR, Jenkins CS, Woods WG, Miles WF, Barclay GR, Fleming SC: Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery. Br J Anaesth 2005, 95: 634-642. 10.1093/bja/aei223View ArticlePubMedGoogle Scholar
- Conway DH, Mayall R, Abdul-Latif MS, Gilligan S, Tackaberry C: Randomised controlled trial investigating the influence of intravenous fluid titration using oesophageal Doppler monitoring during bowel surgery. Anaesthesia 2002, 57: 845-849. 10.1046/j.1365-2044.2002.02708.xView ArticlePubMedGoogle Scholar
- Carrasco G: Instruments for monitoring intensive care unit sedation. Crit Care 2000, 4: 217-225. 10.1186/cc697PubMed CentralView ArticlePubMedGoogle Scholar
- Chaney JC, Derdak S: Minimally invasive hemodynamic monitoring for the intensivist: current and emerging technology. Crit Care Med 2002, 30: 2338-2345. 10.1097/00003246-200210000-00025View ArticlePubMedGoogle Scholar
- Laupland KB, Bands CJ: Utility of esophageal Doppler as a minimally invasive hemodynamic monitor: a review. Can J Anaesth 2002, 49: 393-401.View ArticlePubMedGoogle Scholar
- Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM: CDC definitions for nosocomial infections. Am J Infect Control 1988, 16: 128-140. 10.1016/0196-6553(88)90053-3View ArticlePubMedGoogle Scholar
- Pradl R, Chytra I, Kasal E, Bosman R, Židková A: Early hemodynamic optimization in multiple trauma patients by transesophageal Doppler. Intensive Care Med 2004, 30: s130.Google Scholar
- Chytra I, Pradl R, Bosman R, Pelnář P, Kasal E, Židková A: Optimization of intravascular volume in multiple trauma patients using esophageal Doppler – preliminary results. Anest Intenziv Med 2006, 17: 156-163.Google Scholar
- Pearse R, Dawson D, Fawcett J, Rhodes A, Grounds M, Bennet D: Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]. Crit Care 2005, 9: R687-693. 10.1186/cc3887PubMed CentralView ArticlePubMedGoogle Scholar
- Bakker J, de Lima AP: Increased blood lactate levels: an important warning signal in surgical practice. Crit Care 2004, 8: 96-98. 10.1186/cc2841PubMed CentralView ArticlePubMedGoogle Scholar
- Arkilic CF, Taguchi A, Sharma N, Ratnaraj J, Sessler DI, Read TE, Fleshman JW, Kurz A: Supplemental perioperative fluid administration increases tissue oxygen pressure. Surgery 2003, 133: 49-55. 10.1067/msy.2003.80View ArticlePubMedGoogle Scholar
- Bennett-Guerrero E, Welsby I, Dunn TJ, Young LR, Wahl TA, Diers TL, Phillips-Bute BG, Newman MF, Mythen MG: The use of a postoperative morbidity survey to evaluate patients with prolonged hospitalization after routine, moderate-risk, elective surgery. Anesth Analg 1999, 89: 514-519. 10.1097/00000539-199908000-00050PubMedGoogle Scholar
- Bichel T, Kalangos A, Rouge JC: Can gastric intramucosal pH (pHi) predict outcome of paediatric cardiac surgery? Paediatr Anaesth 1999, 9: 129-134. 10.1046/j.1460-9592.1999.9220324.xView ArticlePubMedGoogle Scholar
- Poeze M, Greve JW, Ramsay G: Meta-analysis of hemodynamic optimization: relationship to methodological quality. Crit Care 2005, 9: R771-779. 10.1186/cc3902PubMed CentralView ArticlePubMedGoogle Scholar
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