Volume 2 Supplement 1

18th International Symposium on Intensive Care and Emergency Medicine

Open Access

Variations of veno-arterial and mucosal-arterial CO2 gap during continuous veno-venous hemodiafiltration

  • J-L Chagnon1,
  • F Lambiotte1,
  • F Merlette1,
  • AV Moughabghab1,
  • C Coffinier1,
  • K Blanckaert1 and
  • C Socolovsky1
Critical Care19982(Suppl 1):P133

DOI: 10.1186/cc262

Published: 1 March 1998

Introduction

Veno-arterial CO2 gap (P(v-a) CO2) and mucosal-arterial CO2) gap (P(g-a) CO2 may help to detect tissular dysoxia. Continuous veno-venous hemodiafiltration (CVVHD) technics are well tolerated in septics patients.

Objectives

Change of P(v-a) CO2 and of P(g-a) CO2 during CVVHD.

Methods

Prospective study. Intubated and ventilated patients. Hemodynamics and systemic oxygen derived parameters were collected before and during CVVHD (H0-H6). CVVHD setting parameters (PRISMA®, HOSPAL) were standardised. Gastric mucosal PCO2 continously monitored (NGS (TONOMETRICS) and TONOCAP® (DATEX). P(v-a) CO2 and P(g-a) CO2 calculated. Continuous measure of end tidal CO2 (PetCO2). Statistics: ANOVA, Scheffe t test for paired and unpaired values

Results

7 patients (71.7 ± 5 years, SAPS II = 59.5 ± 3.7) included. PetCO2 and P(v-a)CO2 did not change from H0 to H6. P (g-a)CO2 increased significantly at H1 (*P < 0.05) then progressively decrease but did not reach the initial value.

Results

Conclusion

The marked increase of P(g-a)CO2 during CVVHD could be explained by acid-base status in the mucosa independent of hemodynamics changes.

Authors’ Affiliations

(1)
Réa, Médicale, C. Hospitalier

Copyright

© Current Science Ltd 1998

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