Volume 1 Supplement 1

17th International Symposium on Intensive Care and Emergency Medicine

Open Access

Relationship between brain tissue oxygen (PbrO2) and cerebral perfusion pressure (CPP)

  • P Bruzzone1,
  • G Bellinzona1,
  • R Imberti1,
  • L Carnevale1,
  • S Noli1,
  • M Raimondi1,
  • P Bianchi1 and
  • RV Dionigi1
Critical Care19971(Suppl 1):P008

DOI: 10.1186/cc14

Published: 1 March 1997

Introduction

Ischemia is the leading cause of secondary brain damage after severe head injury (SHI). Adequacy of cerebral oxygenation can be assessed by monitoring: cerebral perfusion pressure (CPP), the driving pressure of cerebral perfusion; oxygen saturation of jugular bulb (SjO2), the ratio between global cerebral oxygen availability and consumption: partial pressure of brain tissue oxygen (PbrO2), the driving pressure of oxygen diffusion to mitochondria at tissue level [1,2].

Methods

Our preliminary evaluation of PbrO2 in 10 patients with SHI (GCS = 8), in which PbrO2 was recorded for more than 7 days along with CPP, is reported. Intracranial pressure (ICP) was measured with an intraparenchymal fiberoptic transducer (Camino Laboratories), PbrO2 was measured with a Cark-Type catheter (Catheter PO2 Micro-Probe, CMP, Licox GMS, Kiel, Germany); CPP was obtained as difference between mean ABP and mean ICP.

All patients, when ICP increased over 20 mmHg, were treated according to a standard protocol: better sedation; moderate hyperventilation; mannitol infusion; barbiturates. Two patients had severe and repeated increases in ICP and eventually underwent surgery for evacuation of hemorrhagic contusion.

Results

Data were collected every minute and analysed recoding CPP values in classes of 5 mmHg between 40 and 90 mmHg and one class for values over 90 mmHg. Using two way analysis of variance with CPP classes and patients as factors, a significant dependency of mean PbrO2 from CPP can be demonstrated.

Conclusions

Although PbrO2, is directly influenced by PaO2, using appropriate statistical methods and a large number of data, significant low PbrO2 values can be associated to a low cerebral perfusion pressure.

Individual PbrO2 values depends from single patient and from PaO2. It is difficult to define precisely a PbrO2 value that can be used as a target for treatment. With PaO2 between 80 and 150 mmHg. PbrO2 values between 25 and 40 are expected, but whatever value decreasing in spite of a constant PaO2 can be regarded is an alarming sign of impinging on cerebral oxygenation

Table

CPP

Mean

sd

95%

Confidence for the

CPP

Mean

sd

95%

Confidence for the

classes

  

mean

 

classes

  

mean

 

40-45

25.79

10.01

24.37

27.20

70-75

37.23

19.76

36.83

37.63

45-50

36.05

10.53

24.96

27.14

75-80

38.35

20.47

37.97

38.74

50-55

25.82

11.73

25.09

26.54

80-85

36.33

20.73

35.95

36.72

55-60

29.60

14.48

28.96

30.24

85-90

35.12

16.53

34.68

35.56

60-65

31.98

18.36

31.46

32.49

>90

28.13

12.58

27.86

28.40

65-70

33.35

19.99

32.91

33.79

     

Authors’ Affiliations

(1)
Intensive Care Unit, 2nd Anaesthesiology Service, IRCCS Policlinico

References

  1. Dings J, Meixensberger J, Amschler J, Hamelbeck B, Roosen K: Brain tissue pO2 in relation to cerebral perfusion pressure, TCD findings and TCD-CO2-reactivity after severe head injury. Acta Neurochir (Wien). 1996, 138: 425-434. 10.1007/BF01420305.View ArticleGoogle Scholar
  2. van Santbrink H, Maas AIR, Avezaat CJJ: Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury. Neurosurgery. 1996, 381: 21-31. 10.1097/00006123-199601000-00007.View ArticleGoogle Scholar

Copyright

© Current Science Ltd 1997

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