Assessment of volume responsiveness during mechanical ventilation: recent advances
© Springer-Verlag Berlin Heidelberg and BioMed Central 2013
Published: 19 March 2013
Predicting which patients with acute circulatory failure will respond to fluid by a significant increase in cardiac output is a daily challenge, in particular in the setting of the intensive care unit (ICU). This challenge has become even more crucial because evidence is growing that administering excessive amounts of fluid is a risk factor in critically ill patients, in particular in patients with lung injury. However, some tests and indices allow prediction of fluid responsiveness before intravenous fluids are infused. In patients receiving mechanical ventilation, the arterial pulse pressure variation (PPV) has been used for many years. More recently, other tests, which may overcome some limitations of PPV, have been developed. In addition, recent studies have emphasized how the hemodynamic effects of volume expansion should be assessed once fluid has been administered.
The concept of predicting fluid responsiveness
For this purpose, 'static' markers of cardiac preload have been used for many years. Nevertheless, a very large number of studies clearly demonstrate that neither pressure nor volume markers of preload can predict fluid responsiveness [7, 8]. This finding is mainly because a given value of preload can correspond to either a large or a negligible response of cardiac output to fluid administration, depending upon the slope of the Frank-Starling curve, which cannot be a priori determined in a given patient (Figure 1). This is the reason why a 'dynamic approach' has been developed for assessing volume responsiveness . The concept is to assess preload-dependency by observing the effects on cardiac output of changes in cardiac preload induced by various tests.
Monitoring respiratory variations in stroke volume: a large base of evidence
Pulse pressure variation
The first application of this 'dynamic' concept consisted of quantifying the variations in stroke volume induced by positive-pressure ventilation . As a result of heart-lung interactions, each mechanical insufflation decreases venous return and, if the right ventricle is preload-dependent, reduces the right ventricular (RV) outflow. Increase in RV afterload induced by increased lung volume contributes to this reduction in RV outflow. In turn, this results in a decrease in left ventricular (LV) preload, which occurs after a delay of a few cardiac cycles, required for the blood to transit through the lungs. In the case of conventional ventilation, this effect should occur at expiration. If the left ventricle is also preload-dependent, the LV stroke volume transiently decreases. As a result, a cyclic variation in stroke volume under mechanical ventilation indicates the existence of preload-dependency of both ventricles .
The arterial pulse pressure (systolic minus diastolic arterial pressure) as a surrogate of stroke volume has been proposed to predict fluid responsiveness through its respiratory variation . A number of studies conducted in various clinical settings have repeatedly demonstrated that PPV actually predicts fluid responsiveness . Among the different indicators of fluid responsiveness, PPV is supported by the highest level of evidence. Importantly, PPV is calculated automatically and displayed in real-time by the most recent bedside hemodynamic monitors.
Other surrogates of stroke volume
Almost all indices that provide a beat-to-beat estimation of stroke volume have been investigated for their ability to test fluid responsiveness by their respiratory variation: Aortic blood flow measured by esophageal Doppler ; subaortic peak velocity measured by echocardiography ; stroke volume estimated from pulse contour analysis . Some recent studies have investigated non-invasive estimations of stroke volume, such as the non-invasive arterial pulse pressure estimated by the volume-clamp method [15, 16] or the amplitude of the plethysmographic waveform . All these non-invasive methods still require confirmatory studies, but they may be of great interest for the perioperative management of low-risk surgical patients, when there is no need for an invasive monitoring device.
Finally, analysis of respiratory variations of the diameter of the inferior vena cava (using transthoracic echocardiography)  or of the superior vena cava (using transesophageal echocardiography)  can also be used to assess fluid responsiveness in mechanically ventilated patients.
Limitations of the respiratory variation in stroke volume for predicting fluid responsiveness
The use of respiratory variation of stroke volume or surrogates to predict fluid responsiveness has some limitations that are now clearly identified. The first and most important limitation is the presence of some spontaneous breathing activity . When a patient has some breathing efforts under mechanical ventilation - and even more when the patient is not intubated - the variation in intrathoracic pressure is not regular, neither in rate nor in amplitude, such that the variation in stroke volume cannot relate to preload-dependency [21–23]. Thus, using the respiratory variation of stroke volume to test the preload sensitivity is valid only in cases of coma or deep sedation during mechanical ventilation, a condition that has become less frequent in the ICU.
A second limitation of using the respiratory variation in stroke volume is the presence of cardiac arrhythmias as in these cases, the variation in stroke volume is obviously more related to the irregularity of diastole than to heart-lung interactions.
A third limitation refers to conditions in which the variations in intravascular pressure induced by mechanical ventilation are of small amplitude. In the case of low tidal volume, the small variations in intrathoracic pressure may not be sufficient to trigger significant preload variations, even in cases of preload responsiveness. Some studies have actually shown that PPV loses its predictive value in the case of low tidal volume [24, 25]. The changes in intravascular pressure induced by mechanical ventilation may also be reduced if the transmission of changes in alveolar pressure to the pressure of the intrathoracic structures is attenuated, e. g., in the case of low lung compliance. A recent clinical study demonstrated that if the compliance of the respiratory system is less than 30 ml/cm H2O, the value of PPV for predicting fluid responsiveness is dramatically reduced, independently of tidal volume .
A fourth limitation is the use of high frequency ventilation. If the ratio of heart rate to respiratory rate is low, e. g., if the respiratory rate is elevated, the number of cardiac cycles per respiratory cycle may be too low to allow respiratory stroke volume variation (SVV) to occur ; nevertheless, this applies to respiratory rates as high as 40 breaths/min .
A fifth limitation is the presence of increased abdominal pressure [28, 29]. In such cases, a higher PPV cut-off value must be considered for the prediction of fluid responsiveness . Finally, open-chest surgery is another situation where the ventilation-induced variation of hemodynamic signals loses its predictive value for fluid responsiveness .
Alternatives to the respiratory variation of hemodynamic signals: recent advances
The end-expiratory occlusion test
This test is another method that takes advantage of heart-lung interactions to predict fluid responsiveness in ventilated patients. During mechanical ventilation, each insufflation increases the intrathoracic pressure and impedes venous return. Thus, interrupting the respiratory cycle at end-expiration inhibits the cyclic impediment in venous return. The resulting increase in cardiac preload may thus help to test preload responsiveness (Figure 1). Indeed, it was demonstrated that if a 15-second end-expiratory occlusion test increased the arterial pulse pressure or the pulse contour-derived cardiac output by more than 5%, the response of cardiac output to a 500 ml saline infusion could be predicted with good sensitivity and specificity . Noticeably, all patients of the latter study were arrhythmic or had mild spontaneous breathing activity. These initial results were recently confirmed .
Beyond its simplicity, the main advantage of the end-expiratory occlusion test is that it exerts its hemodynamic effects over several cardiac cycles and thus remains valuable in case of cardiac arrhythmias . Also, the end-expiratory occlusion test can be used in patients with spontaneous breathing activity, unless marked triggering activity interrupts the test. Another limitation is that the effects of the end-expiratory occlusion test, which must be observed over 15 s, are much easier to observe on a continuous display of cardiac output than on the arterial pulse pressure because the value of the latter is not continuously calculated and displayed by bedside monitors.
The 'mini' fluid challenge
Obviously, the easiest way to test preload responsiveness is to administer fluid and to observe the resulting effect on cardiac output. Nevertheless, the disadvantage of the 'classical' fluid challenge is that it consists of administration of 300-500 ml of fluid . Because it is not reversible, such a fluid challenge may contribute to fluid overload, especially when it is repeated several times a day .
In this regard, a new method has been proposed for performing a fluid challenge . It consists of administering 100 ml of colloid over 1 min and observe the effects of this 'mini' fluid challenge on stroke volume, as measured by the sub aortic velocity time index using transthoracic echocardiography (Figure 1). In a clinical study, an increase in the velocity time index of more than 10% predicted fluid responsiveness with a sensitivity of 95% and a specificity of 78% .
The first advantage of this test over the classical fluid challenge is obviously that such a small volume of fluid is unlikely to induce fluid overload , even if repeated several times a day. Another advantage is that it is easy to perform and that it can be assessed in a non-invasive way . Nevertheless, a strong limitation is that, even in cases of preload-dependency, such a small volume infusion will unavoidably induce only small changes in cardiac output. This test, therefore, requires a very precise technique for measuring cardiac output. Whether non-invasive techniques, such as echocardiography, are precise enough for this purpose is still uncertain. Finally, this method cannot be used in the presence of cardiac arrhythmias. In the study by Muller et al., one fourth of patients were excluded because of this limitation .
The passive leg-raising test
In a lying subject, raising the legs from the horizontal position passively transfers a significant volume of blood from the lower part of the body toward the cardiac chambers: Passive leg-raising (PLR) partially empties the venous reservoir and converts a part of the unstressed blood volume to stressed volume. In this connection, PLR increases right [35–37] and left [22, 35] cardiac preload. Eventually, the increase in left cardiac preload results in an increase in cardiac output depending upon the degree of preload reserve of the left ventricle. The increase in cardiac preload induced by PLR totally reverses once the legs are returned back to the supine position [22, 35, 36]. In summary, PLR acts like a reversible and short-lived 'self' volume challenge  (Figure 1). As a clinical application of this simple physiological concept, several studies reported that the increase in cardiac output induced by the PLR test enables prediction of fluid responsiveness; many of these studies were included in a meta-analysis . These findings have contributed to establish PLR as a reliable and easy way to predict fluid responsiveness at the bedside . Interestingly, since the test exerts its effects over several cardiac and respiratory cycles, it remains a good predictor of fluid responsiveness in patients with spontaneous breathing activity (even non-intubated) or cardiac arrhythmias [22, 31].
The postural change used for performing the PLR test is important . If PLR is started from the 45° semi-recumbent position, the induced increase in central venous pressure is larger than if started from the supine position . In fact, starting PLR from the semi-recumbent position mobilizes blood coming not only from the inferior limbs but also from the large splanchnic compartment. As a consequence, starting PLR from the semi-recumbent posture is more sensitive than starting from the horizontal posture to detect fluid responsiveness , so that this method should be considered as a standard.
Another important point concerns the method that can be used for measuring the changes in cardiac output during PLR . A real-time measurement able to track hemodynamic changes in the time frame of PLR effects, i. e., 30-90 s, must be used. Indeed, the increase in cardiac output during PLR is not sustained when the leg elevation is prolonged. This aspect is particularly true in septic patients in whom capillary leak may account for an attenuation of the PLR effects after one minute, as already described . This is why clinical studies that have tested the value of PLR to predict volume responsiveness used real-time hemodynamic measurements, such as aortic blood flow measured by esophageal Doppler [22, 41], pulse contour analysis-derived cardiac output [16, 26, 42], cardiac output measured by bioreactance [43, 44] or endotracheal bioimpedance cardiography , subaortic blood velocity measured by echocardiography [46–48], ascending aortic velocity measured by suprasternal Doppler  and, more recently, end-tidal carbon dioxide [50, 51].
Beyond its reliability and ease of use, the PLR test has some limitations . First, its effects cannot be assessed by observing the arterial pressure. PLR-induced changes in arterial pulse pressure are less accurate than PLR-induced changes in cardiac output or stroke volume, as found by several studies . This finding is explained by the fact that arterial pulse pressure is only a rough surrogate of stroke volume. This means that correct performance of a PLR test requires a device that allows a more direct estimation of cardiac output. Second, the PLR test cannot be used in instances in which mobilizing the patient is not possible or allowed, e. g., in the operating room or in the case of head injury .
How to assess the response to volume expansion?
Effects of volume expansion on cardiac output
If the decision is taken to infuse fluid in case of preload reserve, the ensuing question is whether the fluid actually exerts its expected beneficial effects. What is expected from fluid administration is a significant increase in cardiac output. In this regard, it has been recently shown that changes in arterial pressure are relatively imprecise to estimate the effects of fluid infusion on cardiac output [53, 54]. In 228 patients who received a standardized saline infusion, fluid-induced changes in arterial pulse pressure were weakly correlated with the simultaneous changes in cardiac output (r = 0.56) . Consequently, the changes in pulse pressure induced by volume expansion detected a positive response to fluid (i. e., an increase in cardiac output ≥ 15%) with a specificity of 85% but with a sensitivity of only 65%; in other words, 22% of cases were false negatives, meaning that in these patients, fluid administration significantly increased cardiac output whereas the arterial pulse pressure did not change to a large extent. Pierrakos et al. confirmed these results in 51 septic shock patients , in whom there was no significant correlation between fluid-induced changes in arterial pulse pressure and fluid-induced changes in cardiac output. These results are explained by the fact that arterial pulse pressure is physiologically related to stroke volume but also inversely correlated with arterial compliance , which may differ among patients and may change over time in the same patient. Moreover, the proportionality between pulse pressure and stroke volume is physiologically expected at the aortic level, but not at the peripheral arterial level because of the pulse wave amplification phenomenon.
Another important point emphasized by the above cited studies [53, 54], is that the fluid-induced changes in cardiac output are not reflected at all by the fluid-induced changes in mean arterial pressure (MAP). Physiologically, the changes in MAP are dissociated from the changes in cardiac output because of the sympathetic modulation of the arterial tone, which tends to maintain MAP constant while cardiac output varies. These results suggest that precise assessment of the effects of volume expansion should not rely on simple blood pressure measurements but should rather be based on direct measurements of cardiac output. This may be particularly important in patients at risk of fluid overload during sepsis and/or ARDS.
Effects of volume expansion on tissue oxygenation
What is really expected from volume expansion in a patient with acute circulatory failure is not only an increase in cardiac output but also an improvement in tissue oxygenation. This can only occur if oxygen consumption depends on oxygen delivery (DO2). However, this is not always the case. In a recent study, we observed that volume expansion administered in patients with acute circulatory failure increased cardiac output ≥ 15% in 49% of cases ("volume-responders") . Although DO2 significantly increased in "volume-responders", a significant increase in oxygen consumption occurred in only 56% of these patients. When looking at variables that could identify patients who would benefit from volume expansion in terms of oxygen consumption, we found that markers of global tissue hypoxia, such as blood lactate, were more relevant than the central venous oxygen saturation (ScvO2). This illustrates the difficulty of using ScvO2 for assessment of fluid therapy  because ScvO2 cannot detect preload responsiveness  or identify among volume-responders those who will benefit from fluid infusion in terms of tissue oxygenation . Importantly, in our study, DO2 decreased with volume infusion in the "volume-non-responders" (51%), owing to development of hemodilution . This latter finding reinforces the message that identifying volume responders before any fluid administration is crucial since volume expansion in patients without preload-dependency can be deleterious not only on lung function but also on peripheral oxygenation.
There is growing evidence suggesting that overzealous fluid administration is deleterious in critically ill patients, particularly in cases of sepsis and/or lung injury. During recent years, several tests have been developed to detect volume responsiveness before administering fluid. These tests can also serve to detect volume unresponsiveness, which could be helpful at any moment of fluid resuscitation to better assess the benefit/risk ratio of continuing such a strategy . The analysis of respiratory variation in stroke volume has received the largest level of evidence, but cannot be used in cases of spontaneous breathing activity, cardiac arrhythmias, low tidal volume or low lung compliance. Some more recently developed tests, such as the end-expiratory occlusion test, the 'mini' fluid challenge and the PLR test can be used as alternative methods, solving the problem of prediction of volume responsiveness in cases of spontaneous breathing activity and/or cardiac arrhythmias. The ideal management of fluid therapy should also include a precise assessment of the effects of volume expansion on cardiac output and tissue oxygen consumption.
List of abbreviations used
acute respiratory distress syndrome
expiratory occlusion test
extravascular lung water
intensive care unit
mean arterial pressure
pulse pressure variation
central venous oxygen saturation.
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