Volume 5 Supplement 1

21st International Symposium on Intensive Care and Emergency Medicine

Open Access

Malaria and the HIV virus: is there any interaction?

  • I Joubert1,
  • B Zeippen1 and
  • C O'Reilly1
Critical Care20015(Suppl 1):P097

DOI: 10.1186/cc1164

Received: 15 January 2001

Published: 2 March 2001

Objectives

The aim of the study is to see if HIV influences the severity and outcome of Plasmodium Falciparum Malaria.

Design and methods

This is a retrospective analysis of ICU records of patients admitted to the ICU at the Chris Hani Baragwanath Hospital between 1990 and 1999 with a confirmed diagnosis of malaria. 70 of the 152 patients had their HIV status defined, those were reviewed.

Results

See Tables.
Table 1

Characteristics

 

HIV positive (n = 20)

HIV negative (n = 50)

P value

Male/female ratio

12 M

8 F

26 M

24 F

0.454

ICU stay (median/range)

4.5 days

1–16

5 days

0.5–37

> 0.10

Parasitaemia (median/range)

14.5%

1–50%

1%

< 1–71%

> 0.10

WHO criteria (median/range)

5.5

0–11

5

1–12

> 0.10

APACHE II (median/range)

16

10–29

17.5

6–38

> 0.10

Incidence of ARDS

3/20

15%

14/50

28%

0.278

Incidence of ARF

12/20

60%

26/50

52%

0.454

Incidence of ARDS & ARF

3/20

15%

12/50

12%

0.372

Table 2

Outcome

 

HIV positive

HIV negative

P value

Overall mortality

8/20

40%

15/50

30%

0.375

Mortality of ARDS

3/3

100%

11/14

78%

0.571

Mortality of ARF

8/12

66%

13/26

50%

0.410

Mortality of ARDS & ARF

3/3

100%

10/12

83%

0.600

Conclusions

There is no interaction between HIV seropositivity and severe Plasmodium Falciparum Malaria. HIV status does not impact on severity of malaria. The incidence and outcome of Multiple Organ Failure related to Malaria is not significantly different in HIV infected patients.

Authors’ Affiliations

(1)
Intensive Care Unit, Chris Hani Baragwanath Hospital, University of the Witwatersrand

Copyright

© The Author(s) 2001

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