Volume 5 Supplement 1

21st International Symposium on Intensive Care and Emergency Medicine

Open Access

Low dose pentoxifylline (PTX) reduces mortality in an animal model of acute hepatic and multi-organ failure

  • TM Rahman1 and
  • HJF Hodgson2
Critical Care20015(Suppl 1):P081

DOI: 10.1186/cc1148

Received: 15 January 2001

Published: 2 March 2001

Introduction

Pentoxifylline inhibits, release of TNF-α, platelet aggregation and adherence of leukocytes to endothelium. Previous studies report increased mortality following its use.

Methods

AHF is induced by two intraperitoneal (i.p.) injections (500 mg/kg 8 hours apart) of TAA. Four groups were studied (n = 5). Group 1 received TAA only. Groups 2, 3, & 4 followed the protocol for Group 1, however, Groups 2 and 3 were pre-treated for 5 days with once daily high dose PTX (300 mg/kg i.p.) and low dose PTX (25 mg/kg i.p.), respectively. Whereas, Group 4, commenced PTX (25 mg/kg i.p.) post-TAA for 5 days. Mortality was determined at 96 hours in separate groups (n = 5).

Results

See Table.

Table 1

         

Mortality

 
 

AST (iu/l)

PT (s)

Ammonia (μg/ml)

Lactate (mmol/l)

(%)

 

Hours

24

72

24

72

24

72

24

72

96

 

G1-TAA

1553 ± 343

4512 ± 501

26 ± 3

121 ± 12

58 ± 8

134 ± 12

2.6 ± 1.2

6.3 ± 0.4

75

G2-PTX 300 mg/kg

2065 ± 330

5221 ± 528

>121*

>121

117 ± 34*

153 ± 13

3.9 ± 0.5

7.8 ± 0.6

100*

G3-PTX 25 mg/kg

1177 ± 177

2021 ± 43*

23 ± 4

101 ± 13

71.4 ± 9

70.2 ± 10*

3.5 ± 0.1

4.6 ± 0.2*

40*

G4-Post PTX 25 mg/kg

2161 ± 166

5014 ± 299

>121

>121

121 ± 8*

156 ± 12

4.7 ± 0.6*

7.4 ± 0.8

100*

*P < 0.05, mean ± SD.

Conclusion

Pre-treatment with low dose PTX reduces hepatic injury, multi-organ failure and mortality.

Authors’ Affiliations

(1)
Department of Intensive Care Medicine, St Thomas' Hospital
(2)
Centre for Hepatology, Royal Free & University College Hospital

Copyright

© The Author(s) 2001

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