Hepatorenal syndrome: one size does not fit all
© BioMed Central Ltd 2012
Published: 30 March 2012
We read with interest the Acute Dialysis Quality Initiative (ADQI) VIII consensus statements on the treatment of patients with hepatorenal syndrome (HRS) and acute kidney injury . While we appreciate the authors' discussion, we question the hemodynamic recommendations and suggest further areas of study (Section III in ).
Renal perfusion relies upon cardiac output, renal blood flow, and autoregulation. HRS influences cardiac output and systemic vascular resistance, and establishing a pressure gradient across the glomerulus ensures renal blood flow and glomerular filtration rate [2, 3]. In fluid responsive patients, volume resuscitation is a key component of HRS management.
The traditional target mean arterial pressure (MAP) of 65 mmHg to ensure renal perfusion assumes that 'one size fits all' in HRS. The kidneys are in the abdominal compartment, and intraabdominal pressure varies among individuals. The pressure of the compartment during disease states that cause ascites decreases renal perfusion pressure and should be overcome, especially when autoregulation is impaired . In other words, the arbitrary suggestion of increasing the MAP by 10 mmHg (Table 6 in ) may not be enough (or may be too much).
Titrating norepinephrine to a baseline MAP of 65 mmHg plus the intraabdominal pressure  and administering terlipressin or vasopressin (which may constrict the efferent glomerular arteriole ) may be an effective hemodynamic strategy to ensure renal perfusion pressure. Although this recommendation may not be based on grade A evidence, it is physiologically sound (establishes a pressure gradient) and may inspire further studies of hemodynamic management in patients with HRS.
Andrew Davenport, Mitra K Nadim and John A Kellum, for the authors
We thank Drs Parikh and Moitra for their letter concerning our paper reviewing the medical management of HRS . We agree that the hemodynamic alterations of advanced liver disease are complex. Early in the course of cirrhosis the effects of increased splanchnic vasodilatation, primarily due to local nitric oxide synthesis, have limited systemic manifestations. As liver disease progresses, however, systemic vasodilatation develops despite increased visceral sympathetic tone, reninangiotensin-aldosterone activation, endothelin and vasopressin release, leading to a loss of renal auto-regulation , increasing the risk of 'pre-renal' acute kidney injury .
Terlipressin, a potent vasoconstrictor, particularly for the mesenteric circulation, increases renal perfusion pressure. However, the optimum renal perfusion pressure for patients with cirrhosis is unknown . Following coronary artery surgery, renal auto-regulation is impaired and glomerular filtration rates are higher, with a mean arterial pressure of 70 mmHg . Patients with cirrhosis differ in that they may have ascites and right atrial dilatation. Studies in patients with heart failure with elevated right atrial pressures have shown that intra-abdominal pressures even as low as 8 mmHg adversely affect renal function . In patients with cirrhosis, ascitic drainage can be shown to have an almost immediate dynamic effect on renal perfusion, with changes in intra-renal pressure demonstrated with color Doppler assessment of intra-renal blood flow. Further prospective studies are thus required to determine whether there is an optimal target renal perfusion pressure for patients with HRS treated with terlipressin, but these will also need to include assessment of intraabdominal pressure.
Acute Dialysis Quality Initiative
mean arterial pressure.
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