Volume 16 Supplement 1
Frequency, determinants and impact of feed intolerance amongst the critically ill
© Gungabissoon et al.; licensee BioMed Central Ltd. 2012
Published: 20 March 2012
Provision of early and adequate enteral nutrition (EN) to critically ill patients is associated with improved clinical outcomes; however, 50 to 60% of prescribed EN is received. We aimed to characterise the incidence and determinants of intolerance and assess its influence on nutritional and clinical outcomes using the 2009 Critical Care Nutrition Survey (CCNS).
The CCNS survey is a prospective observational cohort study of nutrition practices from over 150 ICUs around the world. Included patients were those that remained in ICU for ≥72 hours and were mechanically ventilated ≤48 hours of admission to ICU. We collected pertinent baseline and outcome data that included nutritional adequacy, ventilator-free days, 60-day mortality and ICU stay. Intolerance was defined as interruption of EN due to gastrointestinal (GI) reasons (high gastric residuals, increased abdominal girth/abdominal distension, vomiting/emesis, diarrhoea or subjective discomfort). In the analysis of intolerance we included each potential effect into a logistic regression analysis to determine its significance.
Nutritional adequacy and clinical endpoints in tolerant and intolerant EN patients
% Calorific adequacy
% Protein adequacy
ICU stay (days)
Time to discharge alive
Intolerance is common amongst the EN ICU population and is associated with poor nutritional and clinical outcomes.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.