The lung and the brain: a dangerous cross-talk
© BioMed Central Ltd 2011
Published: 30 June 2011
Brain or lung injury or both are frequent causes of admission to intensive care units and are associated with high morbidity and mortality rates. Mechanical ventilation, which is commonly used in the management of these critically ill patients, can induce an inflammatory response, which may be involved in distal organ failure. Thus, there may be a complex crosstalk between the lungs and other organs, including the brain. Interestingly, survivors from acute lung injury/acute respiratory distress syndrome frequently have some cognitive deterioration at hospital discharge. Such neurologic dysfunction might be a secondary marker of injury and the neuroanatomical substrate for downstream impairment of other organs. Brainlung interactions have received little attention in the literature, but recent evidence suggests that both the lungs and brain can promote inflammation through common mediators. The present commentary discusses the main physiological issues related to brain-lung interactions.
The study by Quilez and colleagues  in this issue of Critical Care reports morpho-functional and biochemical effects of mechanical ventilation with lower (8 mL/kg) and higher (30 mL/kg) tidal volume (VT) on lung and brain in healthy rats. Mechanical ventilation may have a serious impact on lung structure and function, leading to ventilator-associated lung injury (VALI) as well as promoting damage of peripheral organs, including the brain. In this respect, mechanical ventilation and sedation in healthy and diseased lungs have been reported to be associated with neurologic impairment, memory, and cognitive dysfunction . On the other hand, brain injury may enhance lung damage in experimental settings , probably by promoting a higher rate of pulmonary complications as well as by altering neurologic outcome . Overall, the information in regard to the multiplepathway cross-talk between the brain and lungs is quite limited .
In the study by Quilez and colleagues , different variables, including lung function, plasma, and lung levels of cytokines as well as c-fos gene, were measured. c-fos is a marker of neuronal activation and is correlated with an increase in functional and metabolic activity in the brain, involved in the phenomena of neuronal plasticity, expressed in response to a wide range of stimuli, and implicated in processes such as gene transcription, apoptosis, or proliferation . The main results of the study by Quilez and colleagues can be summarized as follows: (a) independently of higher or lower VT, mechanical ventilation 'per se' (compared with spontaneous breathing) induced neutrophil infiltration, increased lung damage, and was associated with a greater release of inflammatory markers in both the lung and plasma as well as c-fos activation in central amygdala, hippocampus, paraventricular hypothalamic nuclei, and supraoptic nucleus; and (b) higher VT increased c-fos in the retrosplenial cortex and hypotalamus and increased tumor necrosis factor-alpha in the plasma. Therefore, mechanical ventilation promoted brain activation and the intensity of the response was increased with higher VT, suggesting a cross-talk between the brain and lungs.
Brain injury-associated pulmonary dysfunction has long been attributed only to a greatly increased sympathetic activity with pulmonary venoconstriction and higher capillary permeability, but a recent study reported the role of systemic inflammatory response with pulmonary infiltration of neutrophils, cytokine release, and endothelial dysfunction triggered by an initial sympathetic discharge . A clinical study has shown that, after severe brain injury, higher VT was associated with increased risk of acute lung injury (ALI) . On the other hand, ALI itself induces a systemic inflammatory response with elevated cytokines and neutrophils as well as a dysfunction of other organs, including the brain . Protective ventilation could be associated not only with less VALI but also with better cerebral oxygenation and perfusion . Heuer and colleagues  found that acute intracranial hypertension increased extravascular lung water and increased the amount of poorly aerated tissue in previously healthy lungs without alterations in gas exchange. In experimental ALI, intracranial hypertension worsened pre-existing lung damage and further increased brain edema. Conversely, ALI alone increased the circulating concentrations of the neuronal damage markers (neuronal serum enolase and S100B), but the most severe hippocampal damage was seen in animals with combined ALI and intracranial hypertension. This is in agreement with clinical reports [11, 12] and could indicate a reciprocal, synergistic effect of the two conditions.
The study by Quilez and colleagues, despite generating interesting data for the near future, has some limitations. First, small animals were used and thus similar results may not be obtained in larger animals with ALI. Second, rats were ventilated with very high VT (30 mL/kg, which is equivalent to 2,100 mL in average-sized adult humans) . Third, protective mechanical ventilation was not applied since no positive end-expiratory pressure (PEEP) was used. Therefore, the increase in brain damage and inflammation, even with lower VT, could have been avoided by using moderate PEEP levels. Fourth, moderate hypercapnia and low pHa in the low VT group may have affected the results. Also, the duration of the experiment was quite short (3 hours), so that different effects might be observed with longer periods of mechanical ventilation. Lastly, the type of sedation during spontaneous breathing and paralyzing agents during mechanical ventilation may affect lung inflammation [14, 15].
In conclusion, recent data from experimental and clinical studies have shown (a) increased evidence of a cross-talk between the brain and lungs and (b) a reduction in VALI as well as brain injury when protective ventilation is adopted. Thus, early detection of VALI, through clinical signs and measurements of extravascular lung water and of brain injury by measuring specific markers, could help to optimize ventilatory settings and even the overall clinical management of critically ill patients.
acute lung injury
positive end-expiratory pressure
ventilator-associated lung injury
This commentary received financial support from the Centers of Excellence Program (PRONEX-FAPERJ), the Brazilian Council for Scientific and Technological Development (CNPq), the Carlos Chagas Filho Rio de Janeiro State Research Supporting Foundation (FAPERJ), and Coordination for the Improvement of Higher Level Personnel (CAPES).
- Quilez ME, Fuster G, Villar J, Flores C, Martí-Sistac O, Blanch L, López-Aguilar J: Injurious mechanical ventilation affects neuronal activation in ventilated rats. Crit Care 2011, 15: R124. 10.1186/cc10230PubMed CentralView ArticlePubMedGoogle Scholar
- Morandi A, Brummel NE, Ely EW: Sedation, delirium and mechanical ventilation: the 'ABCDE' approach. Curr Opin Crit Care 2011, 17: 43-49. 10.1097/MCC.0b013e3283427243View ArticlePubMedGoogle Scholar
- Heuer JF, Pelosi P, Hermann P, Perske C, Crozier TA, Brück W, Quintel M: Acute effects of intracranial hypertension and ARDS on pulmonary and neuronal damage. A randomized experimental study in pigs. Intensive Care Med 2011. [Epub ahead of print]Google Scholar
- Pelosi P, Ferguson ND, Frutos-Vivar F, Anzueto A, Putensen C, Raymondos K, Apezteguia C, Desmery P, Hurtado J, Abroug F, Elizalde J, Tomicic V, Cakar N, Gonzalez M, Arabi Y, Moreno R, Esteban A, for the Ventila Study Group: Management and outcome of mechanically ventilated neurological patients. Crit Care Med 2011, 39: 1482-1492. 10.1097/CCM.0b013e31821209a8View ArticlePubMedGoogle Scholar
- Gonzalvo R, Martí-Sistac O, Blanch L, López-Aguilar J: Bench-to-bedside review: brain-lung interaction in the critically ill: a pending issue revisited. Crit Care 2007, 11: 216. 10.1186/cc5930PubMed CentralView ArticlePubMedGoogle Scholar
- Sanz O, Estrada A, Ferrer I, Planas AM: Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid. Neuroscience 1997, 80: 221-232. 10.1016/S0306-4522(97)00089-4View ArticlePubMedGoogle Scholar
- Pelosi P, Severgnini P, Chiaranda M: An integrated approach to prevent and treat respiratory failure in brain-injured patients. Curr Opin Crit Care 2005, 11: 37-42. 10.1097/00075198-200502000-00006View ArticlePubMedGoogle Scholar
- Mascia L: Acute lung injury in patients with severe brain injury: a double hit model. Neurocrit Care 2009, 11: 417-426. 10.1007/s12028-009-9242-8View ArticlePubMedGoogle Scholar
- Mascia L, Zavala E, Bosma K, Pasero D, Decaroli D, Andrews P, Isnardi D, Davi A, Arguis MJ, Berardino M, Ducati A, Brain IT group: High tidal volume is associated with the development of acute lung injury after severe brain injury: an international observational study. Crit Care Med 2007, 35: 1815-20. 10.1097/01.CCM.0000275269.77467.DFView ArticlePubMedGoogle Scholar
- Bickenbach J, Zoremba N, Fries M, Dembinski R, Doering R, Ogawa E, Rossaint R, Kuhlen R: Low tidal volume ventilation in a porcine model of acute lung injury improves cerebral tissue oxygenation. Anesth Analg 2009, 109: 847-855. 10.1213/ane.0b013e3181ad5769View ArticlePubMedGoogle Scholar
- Holland MC, Mackersie RC, Morabito D, Campbell AR, Kivett VA, Patel R, Erickson VR, Pittet JF: The development of acute lung injury is associated with worse neurologic outcome in patients with severe traumatic brain injury. J Trauma 2003, 55: 106-111. 10.1097/01.TA.0000071620.27375.BEView ArticlePubMedGoogle Scholar
- Hopkins RO, Gale SD, Weaver LK: Brain atrophy and cognitive impairment in survivors of acute respiratory distress syndrome. Brain Inj 2006, 20: 263-271. 10.1080/02699050500488199View ArticlePubMedGoogle Scholar
- Protti A, Cressoni M, Santini A, Langer T, Mietto C, Febres D, Chierichetti M, Coppola S, Conte G, Gatti S, Leopardi O, Masson S, Lombardi L, Lazzerini M, Rampoldi E, Cadringher P, Gattinoni L: Lung stress and strain during mechanical ventilation: any safe threshold? Am J Respir Crit Care Med 2011, 183: 1354-1362. 10.1164/rccm.201010-1757OCView ArticlePubMedGoogle Scholar
- Hughes CG, Pandharipande PP: Review articles: the effects of perioperative and intensive care unit sedation on brain organ dysfunction. Anesth Analg 2011, 112: 1212-1217. 10.1213/ANE.0b013e318215366dView ArticlePubMedGoogle Scholar
- Moriondo A, Marcozzi C, Bianchin F, Passi A, Boschetti F, Lattanzio S, Severgnini P, Pelosi P, Negrini D: Impact of respiratory pattern on lung mechanics and interstitial proteoglycans in spontaneously breathing anaesthetized healthy rats. Acta Physiol (Oxford) 2011. [Epub ahead of print]Google Scholar