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Volume 16 Supplement 3

Sepsis 2012

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Effects of sesamol against acute kidney injury in cecal-ligation-and-puncture-treated rats

Background

Polymicrobial infection is associated with systemic inflammatory response, which is involved in the pathogenesis and development of acute kidney injury (AKI) [1, 2]. In this study, we examined the effect of sesamol against AKI in cecal-ligation-and-puncture (CLP)-treated rats.

Methods

Rats were given two subcutaneous doses of sesamol (10 mg/kg) 0 and 6 hours after CLP. Serum and kidney tissue were sampled 12 hours after CLP. Renal function and proinflammatory mediators, such as IL-1β, IL-6, and nitrite production were detected. Systemic oxidative stress was assessed by determining nitric oxide, superoxide anion, and xanthine oxidase activities. In addition, inducible nitric oxide synthase (iNOS) expression was also assessed in leukocytes from rats with AKI.

Results

The levels of serum BUN, CRE, IL-1β, IL-6, nitrite, iNOS expression, superoxide anion, and xanthine oxidase activity were significantly higher in rats after CLP. Sesamol significantly inhibited all parameters in CLP-treated rats.

Conclusion

Sesamol attenuated AKI by inhibiting neutrophil-initiated systemic inflammation and oxidative stress in CLP-treated rats.

References

  1. Leithead JA, Ferguson JW, Bates CM, Davidson JS, Lee A, Bathgate AJ, Hayes PC, Simpson KJ: The systemic inflammatory response syndrome is predictive of renal dysfunction in patients with non-paracetamol-induced acute liver failure. Gut 2009, 58: 443-449. 10.1136/gut.2008.154120

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  2. Li YH, Hsu DZ, Liu MY: Sesamol attenuates systemic inflammation-associated acute kidney injury in polymicrobial infectious rats. In Science Against Microbial Pathogens: Communicating Current Research and Technological Advances. Edited by: Mendez-Vilas A. Badajoz, Spain: Formatex Research Center; 2011:504-510.

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Acknowledgements

This study was supported by grants from the National Science Council, Taiwan.

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Chien, S., Li, Y. & Liu, M. Effects of sesamol against acute kidney injury in cecal-ligation-and-puncture-treated rats. Crit Care 16 (Suppl 3), P70 (2012). https://doi.org/10.1186/cc11757

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  • DOI: https://doi.org/10.1186/cc11757

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